Director, (Senior Principal Scientist) Antibody Generation and Engineering

Bayer•Cambridge, MA

16h•$169,680 - $254,520•Onsite

About The Position

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice. At Bayer Pharmaceuticals, our mission is to pioneer innovations that treat the untreatable, cure diseases, and instill hope. Join in if you aspire to make a meaningful impact within a vibrant community of creative and diverse professionals dedicated to transform drug discovery. We believe your career journey should be guided by your distinct skills and ambitions, not merely defined by your job title. Bring in your passion and unique perspective and join us in our mission to transform the future of healthcare through cutting-edge research and innovation. Your unique contributions will help shape the next generation of pharmaceutical advancements and products. We are seeking an experienced and highly motivated Therapeutic Antibody Drug Hunter with a strong background in antibody-drug conjugates. In this role you will provide enterprise-level scientific leadership and orchestrate and influence in a matrix team multiple projects involving antibody-drug conjugates from early research through clinical candidate selection. You will contribute to advance our pipeline by conceiving new ideas, steering complex studies and CROs, and serving as a primary advisor and problem-solver across teams. You will co-create and evolve our strategic positioning, excellence in external and internal capabilities and innovation in alignment with the broader R&D strategy. As one of the organization’s “go-to” leaders for antibody-drug conjugates, you will be translating cutting-edge science into impactful therapeutic opportunities in the field of oncology, cardiovascular research or immunology. The ideal candidate will have a proven track record in leading projects and in developing antibody conjugates with small molecules, oligonucleotides or peptides as the payload.

Requirements

PhD in chemistry, biochemistry, immunology, biotechnology or related field
Long-term experience in Antibody (BMOL) drug discovery with deep knowledge of literature and industry practices
Understanding of the lead generation and lead optimization process up to preclinical development candidate
Proven scientific and project leadership capabilities
Experience in developing antibody conjugates in cardiovascular/renal, oncology or immunology
Good command of the research landscape and market understanding
Knowledge of state-of-the art antibody discovery processes and innovative tools in BMOL research, including data and large data set analysis
Excellent communication and negotiation skills; intercultural skills and team orientation
Enjoys working in self-organized teams owning and accountable for the value chain
Fluent in English and ideally German

Nice To Haves

12+ years of relevant post-PhD experience including 4+ years in industry is preferred, with a proven record of successful team leadership and interaction with collaborators

Responsibilities

Share responsibility and ownership for project and development candidate goals throughout the discovery process as project leader or cross-functional team member
Provide innovative solutions for antibody conjugates to address unmet needs and design differentiated drugs, be an expert for project teams, mentor peers
Lead antibody generation and optimization for developing new potent innovative leads fulfilling their target product profile
Support molecule design and optimization with fit-for-purpose conjugation techniques for antibodies, antibody formats, small molecule payloads, oligonucleotides and peptides
Provide state-of-the-art techniques to the lead generation and optimization process, including lead discovery, antibody design, analytics, conjugation chemistry, separation techniques, and developability assessment
Build interfaces and cooperation with other research units such as disease area discovery units for candidate screening, characterization, selection and structured and efficient data exchange and decision making
Be an active stakeholder of the drug discovery ecosystem at our Boston site, and a catalyst for innovation into the organization using the Boston biotech ecosystem
Be a driver of strategic clarity, co-create strategies and guidance with stakeholders and co-create differentiated product opportunities
Be a driver of innovation and take ownership with your peers to further develop and innovate in antibody and conjugates lead discovery and optimization
Generate and secure intellectual property for all projects
Ensure high safety standards and compliance
Manage resources efficiently