Senior Scientist, Antibody Engineering

Soleil Labs, LLC•South San Francisco, CA

2h•$134,835 - $240,776•Onsite

About The Position

Join our innovative team at TCG Labs-Soleil as an antibody engineering expert! We are seeking a highly skilled and motivated scientist to lead and advance our antibody engineering capabilities within the cutting-edge Biologics Technology Group. In this pivotal role, you will develop and optimize antibody-based therapeutics while integrating computational and structural insights. You will collaborate cross-functionally with scientists across research and early development to drive technical excellence and support our growing pipeline of protein and antibody-based therapeutics.

Requirements

Ph.D. with 5+ years of postdoctoral or industry experience or M.S. with 10+ years of industry experience in antibody discovery, engineering, biochemistry, structural biology, or related fields within biotech or pharm.
Deep expertise in in vitro antibody discovery and optimization, including synthetic and immune library construction for lead identification and optimization.
Proficiency in phage, yeast, or mammalian display technologies for antibody discovery, optimization and affinity maturation.
Strong problem-solving skills with the ability to troubleshoot complex molecular and biochemical challenges.
Demonstrated ability to prioritize tasks and manage multiple projects in a dynamic, fast-paced environment.
Meticulous attention to experimental detail, adept at multitasking and managing concurrent experiments without compromising quality.
Excellent oral and written communication skills, with a track record of presenting scientific findings and contributing to publications or patents.
Strong team player with the ability to lead cross-functional collaborations and with flexibility to adapt to new scientific domains and quickly acquire new techniques.

Responsibilities

Directly contribute to the therapeutic pipeline by developing and optimizing antibody engineering strategies, including humanization, affinity maturation, bispecific and multispecific antibody design, and innovative molecular formats.
Evaluate and implement cutting-edge antibody display technologies (e.g., phage, yeast, or mammalian display) to enhance discovery and screening capabilities.
Collaborate closely with protein sciences, structural biology, and bioinformatics teams to integrate computational design with experimental validation.
Drive technology innovation by staying current with emerging trends in antibody engineering and incorporating advances into the team’s workflows.
Troubleshoot and resolve complex technical challenges related to in vitro antibody discovery, engineering, and characterization.
Work cross-functionally with internal teams and external partners, CROs, and academic collaborators to expand antibody engineering capabilities.
Design, implement, and analyze experiments efficiently, delivering data-driven insights that inform pipeline decisions.