Director, Protein Sciences

Xaira Therapeutics•South San Francisco, CA

1d•$196,000 - $245,000

About The Position

As the Director of Protein Sciences, you are the primary architect of the group's strategic vision. You will autonomously define, prioritize, and execute our protein production and characterization roadmap, proactively driving the protein design team to challenge conventional antibody assumptions and maximize platform innovation while aligning with clinical development objectives. You are a visionary leader who doesn't just manage the status quo—you proactively identify bottlenecks and implement innovative solutions to push our protein sciences capabilities forward. You cultivate a culture of scientific rigor, high performance, and rapid iteration. Taking pride in building and leading a protein sciences team that is at the forefront of protein production, characterization, and drug development. You enjoy mentoring and developing team members to have a passion for drug discovery and developing novel treatments for patients.

Requirements

B.S. or Ph.D in Structural Biology, Protein Biochemistry, or related fields with 10+ years of industrial experience.
Deep experience in designing and optimizing antibody production processes, including fermentation, cell culture, and purification.
Experience in using automation to generate high throughput (1000+) small-scale antibodies and related molecules.
Hands-on experience in utilizing a variety of analytical techniques like HPLC, Mass Spectrometry, BLI, SPR, ELISA, and CE-SDS for antibody characterization.
Analyzing experimental data, drawing conclusions, and providing insights to inform process optimization
Working with cross-functional teams, including research, CMC, and clinical, to ensure alignment and successful product development.
Maintaining detailed documentation of experimental designs, methods, and results in electronic lab notebooks. You are conscientious, detail-oriented, and organized.
Contributing to the preparation of technical reports and regulatory documentation.
Training and mentoring junior team members in protein production and analytical techniques.

Nice To Haves

Background in structural biology (X-ray crystallography or cryo-EM) is highly desirable.
Experience using LIMS and Benchling systems.

Responsibilities

Champion and drive cross-functional integration across diverse research teams—spanning biology, AI design, and engineering—to successfully achieve scientific goals and address complex project demands.
Push the boundaries of protein science capabilities by evaluating and integrating emerging technologies to increase throughput, data quality, and platform efficiency.
Direct and optimize protein production from a range of host organisms (E. coli, cell-free, and mammalian), and a range of throughputs 10 to 1000s at varying volumes.
Qualify all recombinant proteins by spectroscopic (UV, fluorescence), electrophoresis (SDS-PAGE), aggregation (analytical SEC), validated interactions (BLI/SPR), and identity (MS) methods.
Characterize antibodies for therapeutic properties such as binding kinetics, epitope, stability (thermal and pH), polyspecificity, aggregation propensity, etc..
Direct the purification of soluble and membrane proteins using AKTA (and other) purification systems.
Utilize automation systems to ensure efficient and precise execution of experiments.
Collaborate with Process Development to strategize and perform critical experiments required for clinical development. Able to translate research assays to validated assays for the CMC process.
Train and mentor junior team members, providing guidance on experimental design, data analysis, and troubleshooting.
Maintain accurate and detailed records of experiments, protocols, and results in accordance with company standards and regulatory requirements.
Interpret and present scientific findings at research meetings. Provide scientific input and propose follow-up experiments.
Contribute to scientific publications, patents, and presentations to disseminate research findings both internally and externally.