Director, Protein Engineering

Systimmune•Redmond, WA

4d•$180,000 - $240,000•Onsite

About The Position

SystImmune is seeking a Director of Protein Engineering to lead the FUSE team. This is a hands-on scientific leadership role that combines team management, platform ownership, and program-level decision making across the company’s bi-specific, multi-specific antibody, and ADC pipeline. The Director will own and continue evolving the next-generation yeast display platform built to integrate directly with the FUSE automation wet lab, lead a team of scientists and research associates executing display-based discovery and engineering campaigns, and partner closely with discovery biology, antibody discovery, CMC, and computational teams to deliver optimized lead molecules into the pipeline. This is a full-time onsite position at our Redmond, WA location and we will be relocating to our new Bothell, WA facility in fall 2026.

Requirements

PhD in protein engineering, biochemistry, structural biology, molecular biology, bioengineering, or a related field.
Minimum 10 years of industry experience in biologics drug discovery and development.
Minimum 8 years of hands-on experience with yeast display, including library design and construction, FACS-based selection and sorting, deep sequencing analysis, and downstream characterization of selected binders.
Demonstrated experience building or substantially advancing a yeast display platform, including integration with laboratory automation (liquid handlers, automated cell sorters, LIMS, or equivalent).
Track record leading and developing a team of scientists and research associates, with clear examples of hiring, mentoring, performance management, and career progression.
Demonstrated delivery of engineered binders or therapeutic leads into a biologics pipeline, ideally including bi-specific or multi-specific formats.
Strong working knowledge of antibody and binder formats (IgG, Fab, scFv, VHH) and engineering strategies including affinity maturation, stability and developability optimization, and conditional activation.
Excellent scientific judgment and the ability to make timely, decisive calls on campaign strategy, hit triage, and resource allocation.
Strong written and verbal communication skills, with the ability to represent the function to senior leadership and external partners.

Nice To Haves

Experience leading display campaigns alongside complementary discovery modalities (phage display, immunization-derived repertoires, in silico/AI-based design) is strongly preferred.
Experience in oncology biologics, ADCs, or T cell engagers.
Familiarity with computational and machine learning approaches to library design and binder optimization.
Experience presenting at scientific conferences, contributing to patents, and publishing in peer-reviewed journals.

Responsibilities

Lead, mentor, and develop a team of scientists and research associates, setting clear technical direction, performance expectations, and career development paths.
Build team structure, hiring plans, and resource allocation to match pipeline demand; partner with HR on recruiting, onboarding, and retention.
Establish team operating rhythms, including project reviews, technical reviews, and platform roadmap planning.
Own and advance the next-generation yeast display platform, including library design, surface display formats, selection workflows, and downstream characterization.
Drive integration of the yeast display platform with the FUSE automation wet lab, including liquid handling, automated sorting workflows, cell-free expression, and LIMS/data infrastructure.
Define platform performance metrics (throughput, diversity, hit rate, developability) and lead continuous improvement against those metrics.
Evaluate and onboard new technologies, instrumentation, and methodologies; build the case and budget for capital investments where warranted.
Direct display-based discovery and engineering campaigns for bi-specific and multi-specific antibodies, ADC binder components, and effector molecules across oncology programs.
Lead engineering strategy for affinity modulation, stability and developability optimization, epitope masking, conditional activation (pH, protease, etc.), and other novel binder properties.
Represent FUSE on project teams and at portfolio reviews; translate program needs into platform deliverables and timelines.
Ensure data quality, reproducibility, and integrity across the team; oversee SOPs, LIMS usage, and documentation standards.
Use NGS, flow cytometry, and computational tools to inform iterative protein design and lead selection.
Stay current on the protein engineering, display technology, and lab automation landscape; bring relevant advances into the platform.