Director, Portfolio Strategy and Management

Pfizer • New York City, NY

3d • Hybrid

About The Position

The Director, Portfolio Strategy & Management shapes the strategic direction of the Global Hospital & Biosimilars (GH&B) portfolio by developing enterprise recommendations on where the business should grow, defend, improve, simplify, or exit. The Director leads and advises high-priority portfolio assessments, identifies strategic opportunities and emerging business questions, and partners across functions to deliver rigorous, evidence-based recommendations. These recommendations integrate commercial, financial, operational, manufacturing, regulatory, and strategic considerations; clearly articulate trade-offs and enterprise implications; and enable timely decisions through the Global Portfolio Forum and other governance bodies. Success in this role requires maintaining clear, current strategic direction for priority portfolios; advancing assessments in line with business priorities; proactively identifying, sizing, and prioritizing future opportunities; and resolving cross-functional trade-offs to support effective execution. The Director also helps evolve GH&B’s portfolio operating model, assessment methodology, and future opportunity agenda to strengthen enterprise alignment and value creation.

Requirements

• Bachelor's degree with at least 8 years of experience; OR a master's degree with at least 7 years of experience; OR a PhD with 5+ years of experience
• Broad pharmaceutical experience in Commercial, Manufacturing, Supply Chain, Finance, Regulatory, or related functions to solve complex enterprise problems.
• Experience within sterile injectables, biosimilars, specialty medicines, hospital products.
• Experience shaping and influencing significant portfolio, investment, operational, commercial, or strategic business decisions.
• Strong financial acumen, including the ability to interpret business cases, product economics, P&L performance, margin drivers, stranded costs, and capacity trade-offs.
• Demonstrated ability to evaluate competing priorities and make recommendations under uncertainty using incomplete information.
• Experience using portfolio analytics, scenario modeling, visualization tools, or AI-enabled analytical capabilities.
• Experience leading cross-functional initiatives and influencing senior stakeholders without formal authority.
• Strong executive communication skills, including the ability to frame choices, risks, trade-offs, and recommendations for leadership audiences.
• Enterprise mindset with the ability to balance local, functional, and business-unit interests against broader organizational objectives.
• Experience applying, building, improving, or governing portfolio, investment, prioritization, or value assessment frameworks.
• The ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
• Permanent work authorization in the United States.

Nice To Haves

• Strategy consulting, corporate strategy, corporate development, portfolio management, or business transformation experience.
• Experience in manufacturing network strategy, footprint optimization, supply strategy, or portfolio rationalization.
• Demonstrated leadership in enterprise-wide transformation, strategic planning, or portfolio optimization initiatives.

Responsibilities

• Lead Annual Portfolio Review and own portfolio recommendations across GH&B value chains, identifying where to grow, defend, improve, simplify, rationalize, or exit.
• Translate strategic theses into decision-ready recommendations with explicit assumptions, risks, trade-offs, dependencies, and enterprise implications.
• Ensure recommendations balance commercial opportunity, network realities, operational feasibility, financial returns, and long-term enterprise value.
• Present and defend recommendations in the Global Portfolio Forum and other governance forums as required.
• Maintain a current portfolio opportunity pipeline beyond committed programs and proactively elevate emerging opportunities and risks.
• Lead, co-lead, and/or provide strategic advise for high-priority portfolio assessments, determining the appropriate scope, analytical approach, level of evidence, and cross-functional engagement required to progress each opportunity toward a decision.
• Assemble and direct cross-functional teams from Commercial, Manufacturing, Finance, Regulatory, Medical, Quality, Digital, and market organizations as appropriate.
• Determine which opportunities require hands-on leadership, which should be led by project teams with strategic oversight, and which require further evidence before governance consideration.
• Following approval, transition recommendations to execution owners with assumptions, risks, dependencies, and expected value clearly documented.
• Guide recommendations from assessment through governance and transition to execution, ensuring decision requests, supporting rationale, assumptions, risks, dependencies, expected value, and ownership are clearly documented; reassess recommendations when material facts change.
• Own and continuously improve the GH&B value assessment methodology.
• Ensure recommendations are evaluated consistently across financial, commercial, operational, manufacturing, regulatory, and strategic dimensions.
• Define the decision questions, metrics, analytical views, and visualization capabilities needed to generate actionable portfolio insights; apply artificial intelligence-enabled analytics responsibly to identify patterns, outliers, margin erosion, capacity constraints, growth signals, and optimization opportunities while ensuring validated data lineage, transparent assumptions, and appropriate human judgment.
• Define the strategic decision questions, performance measures, and analytical views required to evaluate portfolio health, value creation, and emerging opportunities across GH&B.
• Shape and advance AI-enabled analytics and visualization capabilities that identify material portfolio patterns, outliers, margin erosion, capacity constraints, growth signals, and optimization opportunities.
• Establish scalable and reusable approaches that accelerate the path from business question to decision-ready insight, reducing reliance on bespoke manual analysis and enabling appropriate self-service access.
• Translate portfolio performance signals into actionable optimization opportunities, applying enterprise judgment to size, prioritize, and sequence opportunities within the portfolio pipeline.
• Set expectations for decision-grade portfolio insights by ensuring appropriate data validation, transparent assumptions, traceable data lineage, and human judgment before AI-generated outputs inform enterprise recommendations.
• Build and leverage trusted enterprise partnerships across Commercial, Manufacturing, Finance, Regulatory, Quality, Digital, and market organizations to shape integrated portfolio recommendations and advance shared priorities.
• Anticipate, surface, and facilitate resolution of cross-functional implications, dependencies, and trade-offs during recommendation development, strengthening alignment and reducing downstream execution risk.
• Integrate external perspectives into portfolio strategy by evaluating relevant market trends, competitive developments, evolving customer needs, and industry practices for their potential enterprise impact.
• Represent and advocate for the enterprise perspective when functional, geographic, or market priorities compete, using influence and sound judgment to guide stakeholders toward decisions that optimize long-term portfolio value.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Director