Director, Portfolio Management

Sarah Cannon Research Institute•Usa, TN

1d•Remote

About The Position

As Director, Portfolio Management, you will lead the strategy, execution, and success of a complex, multi‑study clinical research portfolio—playing a pivotal role in advancing clinical trials that matter. This is a senior leadership position for someone who thrives at the intersection of strategy, operations, and partnership and wants to make a visible impact on sponsors, teams, and patients. You will provide end‑to‑end portfolio leadership across the clinical trial lifecycle, ensuring consistent, high‑quality delivery while driving growth, innovation, and operational excellence. This is a fully remote position based in the US; relocation assistance and visa sponsorship are not available.

Requirements

Bachelor’s Degree required
7+ years’ experience in clinical research or project management
Prior people leadership including line management
Minimum 2 years’ experience in an Associate Director or equivalent role managing multiple complex clinical studies concurrently
Demonstrated experience managing clinical trials independently

Nice To Haves

Master’s Degree preferred
10+ years’ clinical research experience
Medical Affairs experience
Cross-functional engagement and evidence-generation support experience
Pharma/CRO management experience
Experience supporting Investigator-Initiated Trials (IITs) including feasibility, start-up coordination, oversight and stakeholder alignment.

Responsibilities

Set the direction for a diverse clinical portfolio, translating strategic priorities into clear, executable plans.
Oversee scope, timelines, resourcing, quality, and financial performance, ensuring strong governance, proactive risk management, and disciplined execution across studies.
Serve as a trusted senior partner to sponsors—leading governance, communications, and issue resolution while strengthening long‑term relationships.
Collaborate with investigators, cross‑functional leaders, and external partners to align priorities and drive successful outcomes.
Collaborate with Business Development and Clinical Development teams to support proposals, expand partnerships, and grow the portfolio.
Establish and sustain a strong operational rhythm that delivers visibility, accountability, and results.
Oversee portfolio‑level KPIs, financial performance, risk and issue escalation, and continuous improvement efforts.
Coach and develop high‑performing teams, foster talent growth, and serve as a key escalation point for complex delivery and client challenges.