Director, Patient Support Strategy & Operations (Remote Eligible)

Denali Therapeutics•South San Francisco, CA

8d•$204,000 - $265,000•Remote

About The Position

Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Director, Patient Support Strategy & Operations will play a critical role in building and scaling patient support and access capabilities for upcoming product launches and ongoing commercialization efforts. This individual will lead the design and execution of patient support programs, including the establishment and optimization of the Patient Access Hub, affordability programs, and provider support pathways. This role requires a strong blend of strategic thinking and operational execution to ensure seamless patient onboarding, efficient therapy initiation, and a high-quality patient and provider experience. The Director will work cross-functionally to align access strategies with commercial goals while ensuring compliance with all regulatory and legal requirements. Location: This is a remote-eligible position; candidates must be able to work core hours aligned with Pacific Time to support collaboration with our South San Francisco-based team. Travel to our SSF headquarters is required at least monthly, with additional visits as business needs require. This role requires periodic travel: • HQ Travel: Approximately 10–15% • Business Travel: Approximately 15–20%

Requirements

Typically requires a BS/BA and 10+ years of experience in pharmaceutical/biotech patient support, access, reimbursement, hub operations, or specialty pharmacy.
Demonstrated experience launching and managing patient support programs, particularly hybrid field/HUB models.
Experience designing and managing patient affordability programs (copay, PAP).
Proven track record managing external vendors and service providers.
Strong expertise in patient support strategy, reimbursement, and HUB operations, with demonstrated ability to design and operationalize scalable, patient-centric programs
Working knowledge of compliance regulations related to copay and patient assistance programs.
Strong understanding of U.S. payer systems, including Commercial, Medicaid, and Medicare (Part B and Part D), and medical vs. pharmacy benefit design
Proven cross-functional collaboration and stakeholder management skills.
Analytical mindset with the ability to leverage data and insights to inform decision-making and continuously optimize program performance
Excellent communication skills with ability to influence across functions
Ability to manage multiple priorities in a fast-paced environment, with strong attention to detail and execution
Should be willing & able to travel (see above)

Nice To Haves

Advanced degree preferred
Experience in specialty or rare disease therapeutic areas preferred.

Responsibilities

Lead the development and execution of strategies to support product launches and lifecycle management.
Design and operationalize Patient Access Hub services, including benefits investigation, prior authorization (PA) support, appeals, and case management.
Establish and refine Patient Assistance Program (PAP) eligibility criteria and access frameworks.
Develop and implement patient affordability programs, including copay assistance and financial support resources.
Define provider support pathways to reduce access barriers and streamline therapy initiation.
Oversee day-to-day Patient Access Hub operations and vendor performance, ensuring high service quality and compliance.
Manage relationships with patient support program vendors and specialty pharmacy partners to support efficient patient onboarding.
Establish standards for case triage, turnaround times, and quality metrics.
Provide oversight for complex access cases, including free drug programs, in partnership with Medical, Legal, and Compliance as appropriate.
Establish and monitor key performance indicators, including: Time-to-therapy, Patient onboarding timelines, HUB performance and compliance metrics, Effectiveness of patient support programs.
Drive continuous improvement initiatives to enhance access, affordability, and operational efficiency.
Leverage data and analytics to inform decisions and optimize program performance.
Ensure all patient support programs operate in full compliance with regulatory and legal requirements.
Contribute to development of SOPs, policies, and governance frameworks for patient support and access.
Partner with Legal and Compliance to manage risk and ensure appropriate program design.
Partner closely with Market Access, Marketing, Distribution, Payer Strategy, Sales, Medical Affairs, Legal, Compliance, and Commercial teams.
Collaborate with the patient services team and Sales leadership to identify provider education needs related to access and reimbursement.
Represent patient support and access in cross-functional forums and contribute to broader commercial strategy discussions.