Director, Medical Affairs Strategic Operations

Immatics • Houston, TX

1d • $200,000 - $240,000 • Remote

About The Position

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Role Overview: The Director, Medical Affairs Operations will lead the operational strategy and execution of Medical Affairs activities with strong business acumen, and an established history of executing and driving medical launch readiness. As a core member of the USMA Leadership Team, this role ensures that strategy is translated into coordinated, high-impact execution across cross-functional stakeholders. This role will partner closely across internal teams and external stakeholders to ensure compliant, efficient, and scalable solutions that support medical strategy, launch readiness, and scientific exchange in our rapidly evolving PRAME franchise.

Requirements

• Bachelor's degree in Life Sciences, Pharmacy, Nursing, Business Administration, or a related discipline required.
• 10 years of experience in Medical Affairs or related functions within biotech or pharmaceutical industries.

Nice To Haves

• Advanced degree preferred (MBA, PharmD, PhD, MS, or equivalent).
• Experience supporting cell therapy, oncology, immunology, or rare disease programs.
• Experience with Medical Affairs technologies (e.g., Veeva CRM, Veeva Vault MedComms, publication management, grant management systems).
• Experience working in the Medical Affairs function, including scientific communications, external engagement, medical congresses, medical compliance, and data dissemination.
• Experience creating strong partnerships across Medical, Commercial, Regulatory and G&A functions.
• Strong strategic planning, project management, operational execution, and ability to thrive in a fast-paced biotech environment.
• Strategic thinker with hands-on execution capability.
• Excellent communication and stakeholder management skills.
• Vendor management experience (scope, quality, timelines, budget, performance)
• Experience launching new products

Responsibilities

• Translate Medical Affairs strategy into aligned goals and cross-functional plans spanning scientific engagement, communications, evidence generation, and launch readiness; enable alignment between US and Global strategies and drive clarity on priorities and execution.
• Partner with the Head of Medical Affairs, Global Commercialization, US Commercial and Market Access, Regulatory and Clinical Development stakeholders to ensure strategic alignment and coordinated execution.
• Lead complex, cross-functional medical workstreams spanning launch readiness, scientific communications, congress strategy, HEOR/IEP coordination, and external engagement strategy for new product launches, indication expansions, and lifecycle management.
• Establish a clear operating rhythm to facilitate strategic planning, budgeting, and business reviews and align with enterprise and global strategic planning efforts.
• Serve as trusted advisor to Medical Affairs Leadership by synthesizing complex clinical, scientific, and market insights into actional recommendations to enable timely decision making, prioritization, planning, and resourcing of Medical Affairs priorities.
• Champion continuous innovation in US Medical Affairs operations, advance new ways of working including AI-enabled insights and data-drive planning to drive simplification, scalability and improved decision Medical Affairs processes.
• Collaborate on implementation and governance of digital platforms for insights management, medical planning, and content review.
• Evolve US Medical Affairs governance frameworks, including Medical Review Committees (MRC), and assess how to effectively coordinate across various enterprise forums
• Partner with Regulatory and Compliance to ensure compliance with US regulatory standards (FDA, GVP, PhRMA Code), internal policies, and legal requirements.
• Develop and maintain dashboards and KPIs to measure Medical Affairs performance
• Analyze operational data to identify trends, risks, and improvement opportunities
• Lead end-to-end execution of grants, investigator-initiated trials, sponsorships, advocacy, and congress programs
• Oversee complex, cross-functional projects, including risk management and executive reporting
• Support development of scalable Medical Affairs plans aligned to launch and growth priorities
• Manage Medical Affairs budget, including forecasting and financial planning
• Lead vendor strategy, selection, and negotiations to optimize value and performance

Benefits

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short- and long-Term disability coverage
• 401(k) with immediate eligibility and company match
• Partially paid parental leave for eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Director