Director, LNP Discovery

CRISPR Therapeutics•Boston, MA

7d•$195,000 - $215,000•Onsite

About The Position

CRISPR Therapeutics is seeking an individual with deep expertise in the RNA delivery space to lead our mRNA delivery efforts. Reporting to the Head of Translational Biology, they will oversee the development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery. The successful candidate must be able to work in a fast paced and highly dynamic Biotech environment. The ideal candidate will be a leader and a great team player with excellent communication skills and an effective, inspiring management style.

Requirements

PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field
10+ years of experience with lipid nanoparticles, siRNA, and protein design
Demonstrated experience successfully translating animal models from mouse to non-human primate
Excellent communication skills (oral and written)
Track record of innovation in LNP research, spanning bioconjugation, protein design and/or binder design
Strict record keeping skills (eLN)
Proven team leader with a track record of strong research team leadership
Ability to synthesize various inputs and make recommendations on strategic approaches we can take as a company in the area of LNP research
Ability to operate effectively in both detail and high-level settings and strength in navigating
Ability to think strategically and influence others, and approach challenges with a proactive, ownership mindset

Nice To Haves

Biotech Industry experience
Knowledge of the drug development process

Responsibilities

Oversee the development of novel LNPs (e.g., lipid chemistry, composition, formulation process)
Oversee the development of cell‑based assays and animal models for LNP testing.
Lead LNP Delivery biology efforts, including protein design and bioconjugation to ensure successful LNP optimization
Collaborate cross-functionally with pharmacology and programming teams to achieve key milestones
Drive the company’s RNA extrahepatic delivery strategy, with a particular emphasis on IP and key deliverables
Stay up to date on RNA delivery literature and prepare technical reports and white papers
Prepare technical documents and manuscripts for IP filings and publications
Present scientific findings internally and externally at key scientific conferences and industry events