Scientist, LNP Process and Development

Flagship Pioneering, Inc. • Cambridge, MA

1d

About The Position

Serif Biomedicines is seeking a highly motivated Scientist to support the development and scale-up of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on process optimization and scale-up of targeted LNPs encapsulating modified DNA and cofactor mRNA, while also contributing to research efforts aimed at improving LNP design and performance. This is an ideal opportunity for a scientist with a strong background in process development who is interested in expanding into formulation development and early-stage R&D, including formulation screening and optimization of next-generation LNP systems. The successful candidate will work collaboratively within cross-functional teams to advance LNP platform capabilities and support the development of scalable and robust nucleic acid delivery systems.

Requirements

• PhD. in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field, with 3+ years of relevant industry experience; M.S. with 8+ years of experience; or Bachelor with 10+ years of experience.
• Strong background in process development, scale-up, or manufacturing of nanoparticle or LNP-based systems.
• Familiarity with T mixing, or similar, formulation scale-up, and characterization techniques (e.g., DLS, encapsulation assays).
• Demonstrated ability to design experiments, analyze data, and solve complex technical problems.
• Strong communication and collaboration skills.

Nice To Haves

• Experience working with nucleic acid formulations (e.g., mRNA, DNA) is highly preferred.

Responsibilities

• Support process development and optimization activities for LNP formulation and scale-up, including mixing parameters, encapsulation efficiency, and reproducibility.
• Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA.
• Collaborate with internal and external teams to support characterization and evaluation of LNP formulations.
• Assist with technology transfer and scale-up activities, including coordination with external partners or internal manufacturing teams.
• Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams.
• Stay current with advancements in LNP technologies and nucleic acid delivery approaches.

Benefits

• Competitive compensation and benefits package
• healthcare coverage
• annual incentive program
• retirement benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree