Director, Externally Sponsored Research

Revolution Medicines • Redwood City, CA

2d • $211,000 - $264,000 • Hybrid

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:
The Director, Externally Sponsored Research (ESR) (including investigator sponsored trials and collaborative research) will lead the strategy, oversight, and execution of Revolution Medicines' ESR processes within one of our disease areas. This role will ensure scientific rigor, compliance, and alignment of the ESR program with company and external regulatory guidelines. The individual will collaborate closely with internal and external stakeholders to drive excellence in external research. Specifically, this individual will partner with Medical Strategy, Clinical Operations, and others on strategic development and execution of the program. The opportunity involves leadership of ESR-specific scientific committees and broad visibility within the organization. The Director, ESR, reports to the head of the ESR program.

Requirements

• Advanced scientific or medical degree (PhD, PharmD, MD).
• 10+ years of experience in Medical Affairs and ESRs within the biotechnology or pharmaceutical industry.
• Proven ability to develop and execute medical research strategies aligned with company and scientific priorities.
• Experience in ESR program leadership, including proposal review, funding allocation, and study execution.
• Ability to navigate cross-functional partnerships with Legal, Compliance, Regulatory, and Clinical teams.
• Strong analytical and strategic thinking skills with the ability to assess research proposals for scientific merit and alignment.
• Excellent communication, interpersonal, and presentation skills to engage internal and external stakeholders effectively.
• Deep knowledge of global regulatory requirements for Medical Affairs, including FDA, EMA, ICH, GVP, and industry best practices.

Nice To Haves

• Prior experience in oncology, precision medicine, or targeted therapies.
• Familiarity with digital tools and platforms for grant submissions and ESR management.

Responsibilities

• Oversee the end-to-end ESR process for a specific disease area, including development of areas of interest, proposal review, approval, funding, and execution.
• Help set scientific and strategic objectives and ensure that ESRs align.
• Represent ESR program within the organization.
• Lead cross-functional scientific committees in proposal and protocol reviews.
• Maintain compliance with regulatory and legal requirements.
• Monitor ongoing ESRs progress, ensuring milestone tracking, study reporting, and data dissemination.
• Optimize ESR program scalability and operational efficiency, including systematic tracking of proposals, funding allocations, and study outcomes.
• Directly supervise the ESR manager assigned to the program.
• Serve as a key point of contact for ESR-related interactions with internal and external stakeholders.
• Partner with Clinical Operations on execution of the ESR program, including contracting, budgets, enrollment, and metrics.
• Work closely with Medical Affairs, Clinical Development, Preclinical, and other teams to align ESR funding with strategic priorities.
• Build relationships with external medical and scientific communities, including external investigators, KOLs, and cooperative groups.
• Ensure timely and transparent communication with investigators, maintaining strong external partnerships.

Benefits

• competitive cash compensation
• robust equity awards
• strong benefits
• significant learning and development opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree