Director, Evidence Generation Strategy and Operations

Nuvation Bio • Remote - Any State US, NY

6d

About The Position

Nuvation Bio is seeking a strategic and execution-oriented Director, Evidence Generation Strategy and Operations to lead the planning, prioritization, and operational oversight of all non-registrational evidence generation activities across our oncology portfolio. This role will serve as a matrix leader across Medical Affairs, Clinical Development, Commercial, Market Access, HEOR, and external collaborators to ensure an integrated evidence generation strategy that supports lifecycle management, differentiation, and value demonstration for our commercial-stage product and late-stage pipeline asset.

Requirements

• 10+ years of relevant experience in Medical Affairs, Evidence Generation, HEOR, RWE, Clinical Research, or related functions within biotech/pharma.
• Experience in oncology strongly preferred.
• Demonstrated experience leading non-registrational evidence generation strategies across marketed and/or late-stage products.
• Experience managing or overseeing ISR programs, collaborative research, and/or externally sponsored studies.
• Experience managing RWE and HEOR projects inclusive of evidence generation frameworks.
• Strong understanding of the role of evidence in medical, payer, and commercial decision-making.
• Proven ability to lead in a matrixed organization without direct authority.
• Strong program management and operational execution skills.
• Strategic thinking and prioritization
• Executive presence and communication
• Cross-functional influence and collaboration
• Operational rigor and attention to detail
• Scientific and business acumen
• Problem-solving and adaptability
• Vendor and budget management
• As an action-oriented self-starter, you’re eager to apply your expertise in diagnosing inefficiencies, determining root causes, and recommending solutions to complex challenges.
• You establish and nurture highly effective relationships with colleagues and key stakeholders that support and advance project goals and objectives.
• Thorough understanding of clinical methodologies and providing sound analytical support, you quickly establish credibility as a reliable resource.
• Emotional intelligence, curiosity, and a knack to figure out a way to build something better
• Effectively listens, conveys, and receives ideas. Maintains a consistent flow of information. A strong presenter and effective communicator with the ability to influence stakeholders.
• Acts with a clear sense of ownership - whether the task is in their role description. Holds yourself and others accountable to execute all tasks at hand through seen and unforeseen circumstances with high quality and integrity.
• Can manage in an environment of ambiguity. Embraces the change of a new system, process, technology, or idea in the organization. You could reassess priorities, alter goals and take risks.

Nice To Haves

• Advanced degree preferred: PharmD, PhD, MD, MPH, or MS in life sciences, epidemiology, public health, health economics, or related field.
• Experience in a commercial-stage biotech or fast-paced, growth-stage environment.
• Experience supporting product launch / pre-launch evidence planning.
• Familiarity with global evidence generation considerations.
• Alliance Management experience.
• Experience working with oncology-specific real-world datasets and registries.

Responsibilities

• Partner with Medical Strategy Leads to develop and maintain integrated Evidence Generation Plans (EGPs) across the oncology portfolio, ensuring alignment with lifecycle management objectives.
• Identify and prioritize evidence gaps across clinical, economic, and real-world settings to inform evidence generation investments.
• Partner with Clinical Development, Commercial, and Market Access to align evidence strategies with product differentiation and value demonstration goals.
• Translate strategic business and scientific objectives into actionable evidence-generation initiatives.
• Serve as a matrix leader across internal functions including: Medical Affairs, Clinical Development / Clinical Operations, Biostatistics / Data Science, HEOR / Market Access, Commercial / Marketing, Legal / Compliance, Alliance / Business Development.
• Facilitate governance, prioritization, and decision-making forums for evidence generation programs.
• Drive alignment across internal stakeholders and external partners on study priorities, timelines, and deliverables.
• Oversee strategy, intake, review, prioritization, and tracking of Investigator-Sponsored Research (ISRs).
• Partner with Medical Strategy Leads, Field Medical and external investigators to ensure studies align with scientific and business priorities.
• Lead or support collaborative research initiatives with academic institutions, cooperative groups, and research networks.
• Ensure proper oversight of budgets, milestones, contracts, and deliverables for externally sponsored research.
• Provide coordination and operational oversight for HEOR and RWE studies, including: Burden of illness studies, Treatment pattern analyses, Comparative effectiveness research, Economic models / cost-effectiveness analyses, Retrospective/prospective observational studies, Patient-reported outcomes / quality-of-life research.
• Partner with Market Access and HEOR teams to generate evidence supporting payer engagement and reimbursement strategies.
• Evaluate and recommend data sources, research partners, and methodologies for RWE generation.
• Build and manage evidence-generation operational processes, governance, and tracking systems.
• Oversee study timelines, budgets, contracts, milestones, and vendor management.
• Establish KPIs and dashboards to monitor portfolio performance and communicate progress to leadership.
• Ensure studies are conducted in compliance with internal SOPs, regulatory guidance, and applicable laws.

Benefits

• Competitive Base Salary, Bonus, and Equity Plans
• Unlimited Vacation and 10 Sick Days Annually
• Excellent Medical, Dental, and Vision Coverage
• 401K with Company Matching
• full range of medical, financial, and/or other benefits, depending on the level and position offered.

What This Job Offers

• Job Type: Full-time
• Career Level: Director