Director, Data Governance, Quality and Enablement

Madrigal Pharmaceuticals•Waltham, MA

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Director, Data Governance, Quality & Enablement will lead the development and execution of capabilities that ensure enterprise data is trusted, compliant, high-quality, discoverable, and accessible across the organization. This role will lead the implementation of data governance, data quality, metadata, lineage, cataloging, data product controls, and data enablement capabilities across the enterprise data ecosystem. The Director will partner closely with Data Engineering & Platform, Data Products & Analytics, Enterprise Integration, IT Security, Privacy, IT Compliance, and business Data Owners and Stewards to embed governance and quality directly into data pipelines and data products . The role will enable trusted data consumption across analytics, operational integrations, automation, and AI use cases , while ensuring appropriate controls and standards are consistently applied across the enterprise data lifecycle.

Requirements

10+ years of progressive experience in data governance, enterprise data management, data quality, or related disciplines, including 5+ years in leadership roles building or scaling enterprise data governance capabilities.
Demonstrated experience designing and operationalizing enterprise or federated data governance frameworks , including data ownership, stewardship, policies, standards, decision rights, and governance operating models.
Strong knowledge of data quality, metadata management, data cataloging, lineage, master and reference data, data classification, data products, and semantic models , with experience embedding governance and quality controls into modern data platforms and engineering processes.
Strong understanding of data governance and control frameworks and industry standards , such as DAMA-DMBOK, DCAM, NIST, or comparable frameworks, with the ability to translate standards into pragmatic, scalable enterprise practices.
Experience supporting data environments subject to SOX and financial reporting controls , including an understanding of data lineage, access controls, change management, data integrity, auditability, and evidence requirements relevant to financial reporting.
Experience operating within highly regulated environments , pharmaceutical, biotechnology, or life sciences experience strongly preferred.
Working knowledge of GxP principles, data integrity expectations, and regulated data practices is highly desirable.
Understanding applicable privacy, security, records retention, and data protection requirements , with demonstrated experience partnering with IT Security, Privacy, IT Compliance, Internal Audit, Finance, and other control functions.
5+ years of experience owning and administering enterprise data catalog and governance platforms, with proficiency in Alation or comparable technologies (e.g., Microsoft Purview, Collibra, Informatica), including data cataloging, metadata management, lineage, stewardship workflows, data discovery, and access governance.
Experience with modern cloud data platforms, data governance, and analytics technologies.
Experience with Microsoft Fabric, Microsoft Purview, Alation, Power BI, Azure, or comparable technologies is preferred.
Demonstrated ability to establish governance by design , integrating data quality, metadata, lineage, security, compliance, and other controls into data pipelines and data products without unnecessarily slowing business delivery.
Proven ability to influence senior business and technology leaders across organizational boundaries , establish accountability, and drive adoption of enterprise standards in a federated operating environment.
Strong executive communication, stakeholder management, change leadership, and organizational transformation skills , with the ability to translate complex data and regulatory concepts into clear business outcomes.
Experience working in Agile environments with JIRA and Confluence for project planning, sprint execution, and documentation.
Strong leadership, communication, and stakeholder-management skills with the ability to influence technical and business teams and drive strategic outcomes.

Responsibilities

Develop and execute the IT data governance roadmap in alignment with enterprise data strategy and business priorities.
Establish technical governance standards and controls across the enterprise data platform.
Implement scalable governance capabilities for data classification, ownership, metadata, lineage, quality, access, and lifecycle management.
Partner with business functions to operationalize Data Owner and Data Steward responsibilities.
Translate enterprise policies, regulatory requirements, and business expectations into practical technology standards and controls.
Establish governance processes that enable rapid delivery while maintaining appropriate controls.
Establish the enterprise technology framework for data quality and data observability.
Define reusable patterns for profiling, validation, monitoring, reconciliation, and exception management.
Partner with Data Engineering teams to embed automated quality controls directly into pipelines.
Establish quality gates across ingestion, transformation, and data-product publication.
Implement monitoring and scorecards for critical data products and Critical Data Elements.
Drive root-cause analysis and remediation of systemic data-quality issues.
Establish measurable data-product health and reliability standards.
Lead implementation and adoption of enterprise metadata, catalog, and lineage capabilities.
Establish technical metadata standards across pipelines, lakehouses, semantic models, integrations, and data products.
Enable automated lineage from source systems through transformation to downstream consumption.
Partner with business Data Stewards to connect technical metadata with business definitions and context.
Improve enterprise data discovery and reuse through searchable, governed data catalogs.
Establish the technical standards required for a data asset to become a certified enterprise data product.
Define minimum requirements for ownership, metadata, lineage, quality, security classification, documentation, SLAs, and lifecycle management.
Partners with Data Engineering and Data Products & Analytics teams to embed these requirements into development processes.
Establish automated certification and quality controls wherever practical.
Promote reuse of trusted enterprise data products rather than creation of duplicate datasets and pipelines.
Establish technology-focused data enablement programs supporting responsible self-service.
Develop standards, templates, documentation, playbooks, and reusable patterns.
Partner with Data Products & Analytics to establish governed self-service analytics practices.
Build communities of practice and enablement programs for data and analytics practitioners.
Improve adoption and reuse of certified enterprise data assets.
Enable users to find and understand available enterprise data without depending on IT for every request.
Partner with IT Security, IT Compliance, Privacy, Legal, and Quality functions to translate enterprise requirements into data-platform controls.
Ensure appropriate data classification, access, retention, lineage, auditability, and usage controls are implemented across enterprise data capabilities.
Support evidence collection and technology controls required for internal and external audits.
Ensure data solutions follow applicable company policies and regulatory requirements.
Partner with engineering and architecture teams to ensure controls are scalable.
Establish data standards necessary to support trusted consumption by AI and advanced analytics solutions.
Ensure data products intended for AI consumption have appropriate quality, metadata, lineage, ownership, security, and business context.
Partner with AI teams to establish governed access patterns to enterprise data.
Ensure AI solutions consume trusted enterprise data products.
Own the multi-year Data Governance, Quality & Enablement technology roadmap.
Build and mature the governance capability within Global Data Platform & Analytics.
Lead employees, contractors, strategic partners and technology vendors as appropriate.
Drive automation of governance and quality controls.
Establish measurable standards and KPIs.
Communicate data trust, risk and maturity to senior IT and business leadership.
Balance speed, scalability, compliance and control.