Director, Biotherapeutics Discovery

Biogen•San Francisco, CA

20h•$204,000 - $281,000•Onsite

About The Position

At Biogen, we are committed to discovering, developing, and delivering innovative therapies for people living with serious neurological and immunological diseases. In this role, you will lead biologics efforts for Biotherapeutics Discovery at Biogen’s West Coast Hub in South San Francisco. You will drive cross-functional research and portfolio programs, shape the strategy around tomorrow’s way of discovering biological drugs, and advance discovery innovation in close partnership with colleagues across the broader Research organization including key teams in Cambridge, MA.

Requirements

Ph.D. in biochemistry, immunology, molecular biology, or a related scientific discipline
12+ years of industry experience in biologics drug discovery, including leadership of antibody discovery and optimization programs
Proven success advancing molecules from discovery through candidate nomination
Deep expertise in antibody engineering, molecular design, and biologics discovery workflows
Experience across biologics modalities, including bispecifics, fusion proteins, and conjugates
Demonstrated experience leading and developing scientific teams
Strong track record of cross-functional partnership, including collaboration with disease biology teams
Excellent communication and leadership skills, with the ability to influence scientific direction across teams and sites

Nice To Haves

Experience in translational immunology and a strong understanding of immunology disease biology
Experience partnering with Immunology or Neurology research teams
Background in early target assessment and discovery campaign initiation
Experience identifying and sourcing external innovation through collaborations with CROs, biotech companies, or academic groups
Familiarity with computational design or AI/ML applications in biologics discovery

Responsibilities

Lead and develop a high-performing team while advancing biologics technologies and platform innovation aligned with portfolio priorities
In strong partnership with the Cambridge, MA team, support antibody discovery, engineering, optimization, and candidate selection strategies across discovery programs
Evaluate external innovation opportunities and help shape adoption of next-generation biologics capabilities
Contribute to molecular design strategies, including multi-specifics, novel formats, affinity tuning, epitope targeting, and developability assessments
Partner across functions, including protein engineering, computational design, pharmacology, translational sciences, Immunology, and Neurology, to initiate and shape discovery campaigns
Guide modality and candidate selection based on target biology, mechanism of action, and translational considerations, and support early target assessments that test key biological hypotheses
Coach and mentor scientists, fostering technical growth, scientific excellence, and strong collaboration
Build an inclusive culture of innovation, accountability, and continuous learning

Benefits

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation