Director, Bioanalytical Sciences

Denali Therapeutics•South San Francisco, CA

About The Position

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Requirements

Typically requires 10+ years of relevant industry experience, a PhD in analytical science or related field and 8+ years of management experience; MS or BS candidates with substantial additional experience will also be considered
Deep expertise in bioanalytical sciences supporting biologics and complex modalities in discovery and/or early development, including exploratory PK, biomarkers, and PK/PD assay strategy and data interpretation.
Strong working knowledge of bioanalytical approaches and sound judgment in selecting the right method for the question, molecule, and stage.
Track record of leading through influence in matrixed environments, building cross-functional partnerships, and translating technical data into clear program recommendations.
Understanding of how exploratory bioanalysis interfaces with regulated bioanalysis to best support later stages of drug development, including project transition planning and assay documentation expectations.
Highly effective organizational leadership, people management & talent development skills.

Responsibilities

Define and drive bioanalytical strategy across the portfolio, spanning early discovery through clinical development and adapting to evolving program needs. Primary focus will be aligned with early portfolio needs and the initiation of bioanalytical & omics methods in the emerging portfolio.
Build and scale bioanalytical capabilities, including assay platforms, reagent strategies, and technologies that support both early and late-stage programs
Establish and integrate new analytical methods using internal and external resources to ensure efficient and high-quality data generation.
Provide scientific leadership in development and application of bioanalytical methods, including PK, biomarker, immunogenicity, and PK/PD approaches
Partner with cross-functional stakeholders to inform program strategy and decision-making across all stages of development
Lead and develop a bioanalytical team, implementing flexible resourcing approaches aligned to portfolio priorities
Set direction for assay reagent generation, procurement, and prioritization to support a range of modalities and development stages
Guide bioanalytical contributions to regulatory strategies and submissions, ensuring readiness and compliance where applicable
Drive continuous improvement and innovation in bioanalytical workflows, technologies, and operating models
Ensure quality, rigor, and consistency of bioanalytical data to support research and development decisions