Senior Principal Scientist - Bioanalytical Sciences
About The Position
Regeneron's Assay Development Group (ADG) in Bioanalytical Sciences, located in Tarrytown, NY, is seeking a Senior Principal Scientist. In this role, you will create and execute novel assay strategies for all biotherapeutic modalities, designing experiments, troubleshooting problems, organizing and interpreting experimental results, and performing follow-up experiments. Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, Regeneron has nine FDA-approved treatments and numerous product candidates in development, almost all homegrown. Their medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases, and rare diseases. Regeneron is recognized for its award-winning culture of innovation, including being a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020.
Requirements
- PhD degree with 5+ or a MS with 8+ or a BS with 10+ years meaningful experience.
- An in-depth understanding of the science and technology on the development and validation of immunoassays is required.
Nice To Haves
- Stimulates, develops, and promotes the scientific and career development of direct and indirect reports.
- Can act as a leader within the group that effectively drives projects forward to meet aggressive timelines.
- Can communicate effectively with supervisor, upper management/senior leaders and other members within the company and/or outside vendors to obtain assay-related reagents or discuss reagents needs.
- Propose innovative solutions and troubleshooting to address scientific complexity and challenges.
- The ability to perform sophisticated technical tasks to pursue projects that incorporate a diverse set of skills and work on multiple projects/experiments simultaneously.
Responsibilities
- Develop bioanalytical assay approaches for pharmacokinetic, biomarker assays and immunogenicity assays for a diverse pipeline of novel biotherapeutics, including monoclonal antibodies, bispecifics, antibody-drug conjugates (ADC), adeno-associated virus (AAV), CAR-T, RNA as well as drug target biomarkers to support non-clinical and clinical studies.
- Supervise a team of scientists in the development and validation of immunoassays for the measurement of drug, drug complexes and anti‑drug antibodies to support new programs.
- Guides the designs and execution of immunoassays (PK, PD and ADA) by direct reports, based on protocols provided by literature, seminars and other scientists.
- Suggests troubleshooting experiments for assay-related problems follow-up experiments to further assay development and optimize assays.
- Routinely reviews data for multiple developmental projects, working on these projects simultaneously.
- Summarizes and presents results internally to management and externally in industry meetings.
- Writes/reviews assay validation protocols, reports and SOPs prior to submission to Quality Auditing (QA).
- Functions as Study Director for assay validation studies conducted by direct reports.
Benefits
- health and wellness programs (including medical, dental, vision, life, and disability insurance)
- fitness centers
- 401(k) company match
- family support benefits
- equity awards
- annual bonuses
- paid time off
- paid leaves (e.g., military and parental leave)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
