Cryo-EM Scientist

Universities of Wisconsin•Madison, WI

1d•$65,000 - $75,000•Onsite

About The Position

The UW-Madison Cryo-EM Research Centers comprise two facilities, the UW-Madison Department of Biochemistry Cryo-EM Research Center and the NIH-funded Midwest Center for Cryo-ET. Together, these Centers house state-of-the-art cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) instrumentation, including multiple Titan Krios TEMs, a Talos Arctica TEM, cryo-FIB-SEMs, and advanced sample preparation and computational infrastructure. These technologies support bioscience researchers from academia and government, and private industry. The Cryo-EM Scientist will be responsible for training new center users; operations of the instruments on behalf of users; developing advanced analytical techniques on behalf of the centers; staying abreast of advances within the community in order to incorporate those techniques within the centers; and representing the centers within the broader community at meetings, conferences, exhibits, and through peer-reviewed publications. This position is an excellent opportunity for an individual to work with cutting-edge instrumentation for Cryo-EM, cryo-ET, micro-ED, and cryo-FIB milling in state-of-the-art Cryo-EM research facilities. Ideally, we are looking for a colleague with previous EM, Cryo-EM, light microscopy, or structural biology experience. There are ample opportunities for team training in all Cryo-EM modalities. This Cryo-EM Scientist will work with other center scientists as a team to support the missions of the Cryo-EM research centers. However, this individual should be self-motivated and able to work independently on a range of projects and tasks. This Cryo-EM Scientist will join a team of scientists and administrative staff to support the growing Cryo-EM research resources and community at UW-Madison. This is a full time, 100%, ongoing/renewable appointment.

Requirements

Relevant research experience in the biological sciences that could include an understanding of cell biology, microbiology, protein biochemistry, or another appropriate sub-discipline.
Experience with microscopy including light microscopy (fluorescence), electron microscopy, and/or cryo-electron microscopy.
Experience with cryo-preparation techniques such as plunge-freezing, high-pressure freezing, cryo-microtomy, cryo-FIB milling, and other approaches.
Demonstrated ability to effectively communicate and establish relationships with colleagues and collaborators in both oral and written forms of communication.
A demonstrated ability to train or teach effectively.

Nice To Haves

Experience in computational analysis of microscopy and/or Cryo-EM data.
Basic familiarity with both tomographic and single-particle Cryo-EM methods.
Experience in correlating images or data from multiple instruments to both target a region of interest or enhance the total analysis of the sample under study.

Responsibilities

Training new center users
Operations of the instruments on behalf of users
Developing advanced analytical techniques on behalf of the centers
Staying abreast of advances within the community in order to incorporate those techniques within the centers
Representing the centers within the broader community at meetings, conferences, exhibits, and through peer-reviewed publications
Attends and assists with the facilitation of scholarly events and presentations in support of continued professional development and the dissemination of research information
Collects and analyzes research data, conducts experiments and interviews, and documents results according to established policies and procedures under general supervision and limited responsibility
Assists with the identification of research problems and the development of research methodologies and procedures
Serves as a main point of contact and liaison with internal and external stakeholders providing information and representing the interests of a specialized research area
Conducts literature reviews, prepares reports and materials, and disseminates information to appropriate entities
Writes or assists in developing grant applications and proposals to secure research funding