Cryo-EM Scientist

Brookhaven National Laboratory • Ridge, NY

2d • Onsite

About The Position

The national cryo-electron microscopy (cryo-EM) center, the Laboratory for BioMolecular Structure (LBMS) at Brookhaven National Laboratory, provides sample preparation, screening, and high-resolution data collection for both single-particle cryo-EM and cryo-electron tomography (cryo-ET) studies. The facility currently hosts one high-end Krios microscope, one Talos 120C and one JEM 2100 screening electron microscopes, an Aquilos2 cryo-focused-ion beam scanning electron microscope (cryo-FIB-SEM), an EM ICE high-pressure freezer, and cryo-grids preparation equipment. The LBMS is seeking an experienced scientist to join our team and support our efforts in operation and improvement of LBMS cryo-EM capabilities. The cryo-EM scientist will help users obtain high-quality Cryo-EM data, lead cryo-EM efforts on collaboration projects, participate in LBMS 3-tier training program, and develop/implement new methods. The successful candidate will have a strong background in biology, and experience with cryo-EM techniques.

Requirements

• PhD in a relevant field (e.g., biology, biochemistry, biophysics, chemistry, microbiology, virology) with ≥2 years postdoctoral experience.
• Effective and constructive communicator.
• Ability to work both independently as a self-starter and as a proactive team player.
• Ability to maintain a flexible schedule, including evenings and weekends, to support continuous facility operations and user needs.
• Strong organizational and record-keeping skills.
• Experience in at least one of the following: cryo-EM instrumentation, sample preparation, high-resolution single particle data collection, or cryo-electron tomography.

Nice To Haves

• Single-particle image processing using CryoSPARC, Relion, cisTEM, EMAN2, or similar software.
• Tomography image processing using IMOD, AreTomo, EMAN2, or related packages.
• Cryogenic sample preparation using cryo-FIB or cryo-microtome.
• Fluorescence light microscopy for correlative or complementary studies.
• Experience in working in a Linux/UNIX environment.
• Strong record of peer-reviewed publications.

Responsibilities

• Operate and maintain cryo-EMs and related equipment, including sample preparation and image acquisition.
• Train, support and educate users and the public through the 3-tier training program.
• Collaborate with users to design and optimize experiments; provide guidance on sample preparation, data collection, and analysis.
• Communicate with academic and industrial user communities and provide support.
• Contribute to method development in cryo-EM and support overall LBMS operations.

Benefits

• Brookhaven National Laboratory is committed to employee success and we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Review more information at BNL | Benefits Program

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 501-1,000 employees