Computational Biologist

Trans Ova Genetics • Madison, WI

15h

About The Position

URUS is seeking a Computational Biologist to join our Innovation group as part of the team focused on Genetic Advancement and Trait Discovery. This role is suited for a creative and career motivated individual who brings strong expertise across multiple disciplines of genomics, bioinformatics, and systems biology. The successful candidate will lead the integration, analyses and interpretation of genomic and multi-omics data to identify biological pathways, DNA sequence motifs or genomic variation for rationale design of genetic traits to express phenotypes that significantly improve fertility, protein quality, health or well-being across cattle breeding systems. Acceligen ®, as part of the URUS group of brands, is the global leader for deployment of gene-edited traits in cattle. Acceligen has more than a decade of proven commercial expertise in trait deployment through new breeding technologies and advanced reproductive technologies. Acceligen works within a collaborative environment that includes URUS Digital, PEAK Genetics, Trans Ova Genetics, Leachman Cattle CO., and VAS with a common goal to breed “Better Cows for a Better World”. The incumbent will report to the Chief Science Officer of Acceligen , who leads the Genetic Advancement and Trait Discovery team as part of the Innovation group at URUS. This position will be based in Madison, WI or New Brighton, MN. The main objectives of our Innovation team are to better understand genomics and genetics at the molecular level and apply these findings to accelerate genetic improvement and reproductive efficiencies of select proprietary lineages of dairy and beef cattle. The Computational Biologists' goals are to deliver tools and knowledge that facilitate commercial implementation for advancing these goals in the URUS breeding program. The complex nature of the research requires a scientist with a blend of strong biology fundamentals and advanced tech skills (Python/R, ML, stats, databases, high-performance computing) to analyze large biological datasets, model complex systems, and develop predictive tools, alongside possessing creative analytical and problem-solving abilities and interdisciplinary communication skills to bridge biology and computer science for breakthroughs of economic importance to cattle genetics.

Requirements

• Ph.D. in Computational Biology, Systems Biology, Genome Science, or a related field
• Deep understanding of genetics, molecular biology, biochemistry, cellular functions, and organismal systems.
• Expertise in probability, statistical modeling, and algorithm design.
• Principles of programming, data structures, algorithms, high-performance computing (HPC), and database management.
• Knowledge of specific tools, databases, and analysis methods for genomic/proteomic data.
• Proficiency in languages like Python (with libraries like Pandas, NumPy, scikit-learn) and R.
• Experience managing bioinformatics pipelines in Unix/Linux environments.
• Strong skills in data mining, machine learning (deep learning, pattern recognition), and biostatistics.
• Proficient in genome-wide association studies (GWAS) and fine-mapping methods to identify causal variants and regulatory regions.
• Ability to manage, integrate, analyze, and visualize large, complex datasets (e.g. Next- Gen Sequencing data and other Omics datasets).
• Excellent analytical thinking to translate biological questions into computational problems (e.g. demonstrated skill to integrate multi-omics datasets to identify target genes or regulatory motifs/mechanisms within the expressed genome that link genotype to phenotype).
• Required communication skills are fluency in English.
• Ability to explain complex technical findings to both technical and non-technical audiences.
• Skill in formulating hypotheses, finding relevant data, and designing computational experiments.
• Eagerness to learn new methods and tools to tackle evolving biological challenges.
• Precision in coding, data interpretation, and validation.
• Originality and creativity are required to integrate appropriate company resources, methodologies , technologies into a cohesive set of analyses that successfully characterize genome structure and function.
• Originality and creativity are also required to integrate complex datasets from separate functional and structural genome studies into a federated database that channel subsequent studies towards elucidating how alterations in complex biological processes affect phenotypic expression.

Nice To Haves

• Knowledge and experience in working with genomic and genetic data from food animals is preferred.
• Proven experience in identifying causal variants is preferred.
• Knowledge of Snakemake , Microsoft Azure and Azure Databricks is preferred.
• Includes working and communicating within interdisciplinary teams (e.g., molecular and quantitative geneticists, data scientists, and reproductive biologists).

Responsibilities

• Lead the integration, analyses and interpretation of genomic and multi-omics data to identify biological pathways, DNA sequence motifs or genomic variation for rationale design of genetic traits to express phenotypes that significantly improve fertility, protein quality, health or well-being across cattle breeding systems.
• Deliver tools and knowledge that facilitate commercial implementation for advancing these goals in the URUS breeding program.
• Analyze large biological datasets, model complex systems, and develop predictive tools.
• Translate biological questions into computational problems (e.g. demonstrated skill to integrate multi-omics datasets to identify target genes or regulatory motifs/mechanisms within the expressed genome that link genotype to phenotype).
• Analyze, interpret, and report research data.
• Plan specific research approaches and designing experimental schemes to achieve research objectives.
• Contribute to long-term research planning and innovation strategies, which include active participation in team and cross-functional meetings.
• Integrate appropriate company resources, methodologies , technologies into a cohesive set of analyses that successfully characterize genome structure and function.
• Integrate complex datasets from separate functional and structural genome studies into a federated database that channel subsequent studies towards elucidating how alterations in complex biological processes affect phenotypic expression.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree