Computational Biologist

University of Chicago•Chicago, IL

1d•Onsite

About The Position

We are seeking a lifelong learner interested in developing statistical and computational tools to sift through large amounts of data to make discoveries that can improve human health. The Computational Biologist will contribute to the development and application of statistical and computational tools across NIH-funded projects, integrating large-scale GWAS with metabolomics data to uncover mechanisms underlying complex diseases and developing polygenic risk scores that transfer genetic signals across human populations and model organisms to study addiction-related traits, COPD, type 2 diabetes, and other common diseases.

Requirements

College or university degree in related field.
2-5 years of work experience in a related job discipline.

Nice To Haves

Master’s or doctoral degree in computational biology, bioinformatics, statistics, physics, or other quantitative disciplines with an interest in applying skills to biomedical research.
Experience with deep learning in genomics and large language models.
Experience with large datasets, distributed computing, and databases.
Reproducible research tools and workflows (GitHub, Snakemake, Nextflow).
Proficiency in R and/or Python.
Strong Analytical skills.
Problem-solving skills.
Organizational skills.
Verbal and written communication skills.
Ability to work independently and as part of a team
Willingness to explore and adopt new ideas and technologies.
Analytical, statistical, quantitative, and computational/programming skills.

Responsibilities

Analyze large-scale genomic datasets including RNA-seq, whole genome sequence, and single-cell data.
Develop and apply statistical and computational methods to extract biological insights from high-dimensional data.
Develop and train deep learning models to improve upon traditional statistical methods in genomics.
Collaborate with disease and genomics experts to address pressing biomedical research questions.
Write and contribute to scientific publications and present findings at lab and consortium meetings.
Help train and mentor students in the lab.
Applies research principles and relevant subject matter knowledge relevant to administer a research project.
With a moderate level of direction, manages lab and/or research-related duties and tasks.
Helps develop, design and conduct research projects according to plan.
Takes responsibility for the following laboratory duties: recognizing abnormal results and varying conditions or procedures to correct problems; setting up and performing experiments.
Analyze the meaning, significance, causes, and effects of the subject.
Performs other related work as needed.