Clinical Trials Manager

Tango Therapeutics•Boston, MA

2d•$120,000 - $180,000

About The Position

Tango Therapeutics is seeking a Clinical Trial Manager (CTM) to lead operational aspects of clinical trials and support the Clinical Trial Leader (CTL). The CTM is a key member of the Clinical Trial Team (CTT) and the primary contact for external parties and vendors. Depending on the trial, the CTM may lead the cross-functional CTT for smaller, less complex trials, manage critical aspects of larger trials under CTL leadership, or serve as CTL when assigned. The CTM is also responsible for site management oversight when no Site Management Leader (SML) is assigned. In a fast-paced, small biotechnology company, the CTM operationally manages trial setup, conduct, and reporting—or designated portions of those activities—in accordance with approved timelines, budgets, regulatory requirements, and internal standards. The role contributes to the execution and delivery of clinical trial objectives and supports scalable processes, tools, and best practices for efficient, compliant trial execution. Tango Therapeutics is a biotechnology company focused on discovering novel drug targets and developing precision medicines for cancer. Its approach uses the genetic principle of synthetic lethality, including research into tumor suppressor gene loss and cancer cells’ ability to evade immune cell killing. The company’s labs and offices are located in Boston, Massachusetts. The role requires travel as needed, typically 10–20%.

Requirements

At least 5 years of trial management experience.
Bachelor’s degree in Life Sciences, Pharmacy, or a related field.
Experience working in a global clinical development organization.
Experience in outsourcing and oversight.
Knowledge of ICH-GCP, FDA guidelines, EU CTR, and other relevant guidelines.
Knowledge of financial planning, tracking, and reporting.
Knowledge of trial risk assessment and management.
Familiarity with clinical trial systems such as CTMS, eTMF, EDC, IRT, and eCOA, and with site management metrics, KPIs, and KRIs.
Strong vendor management and project management skills.
Leadership skills and the ability to lead cross-functional teams.
Strong interpersonal and communication skills.
Strong analytical thinking and decision-making capabilities.
Willingness to travel as required, typically 10–20%.

Nice To Haves

Leadership experience.
Experience in oncology development.
Direct experience with health authority inspections, including FDA, EMA, or MHRA inspections and sponsor GCP inspections.

Responsibilities

Serve as a core member of the Clinical Trial Team and act as deputy for the Clinical Trial Leader during absences.
Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions.
Facilitate communication and collaboration within the team and with external partners, including CROs and vendors.
Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans.
Establish and manage trial-related systems and processes, such as central laboratories and eCOA/ePRO, in alignment with protocol requirements.
Monitor CRO and vendor performance, ensure timely and accurate data integration, transfer, and reconciliation, and escalate issues to the CTL as needed.
Identify risks and issues and support the development and implementation of mitigation strategies and action plans.
Maintain accurate, up-to-date trial information in systems and communication tools.
Set up and maintain clinical trial insurance in participating countries.
Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator, or co-medication to clinical sites.
Prepare and distribute trial-related correspondence and contribute to materials for meetings, newsletters, and websites.
Lead logistical arrangements and support content development for external meetings, including investigator meetings and advisory boards.
Ensure ongoing inspection and audit readiness, and participate in internal audits and regulatory inspections as required.
Support budget forecasting and accrual processes, and assist with invoice tracking and processing in line with vendor contracts.
When assigned as CTL, lead the cross-functional CTT in operationalizing a clinical trial protocol.
Lead development of the site management oversight plan and ensure site management oversight, including risk management, for trials without an assigned SML.