Clinical Trial Manager

Frontier Medicines•Boston, MA

1d•Hybrid

About The Position

Frontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance of our Director/Sr. Director, Clinical Operations, you will serve as a key operational contact for our CROs and trial sites, helping drive feasibility assessments, site selection, start-up, maintenance, and close-out. This is a great opportunity for someone who wants hands-on ownership of trial execution at a growing, clinical-stage biotech, with direct exposure to program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA office, with an expectation of 2-3 days per week onsite, plus periodic travel to trial sites and CRO/vendor meetings as needed.

Requirements

Bachelor's degree in a scientific, healthcare, or related field, or an RN, required.
3-4 years of Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology clinical trials.
Experience supporting oncology studies strongly preferred.
Vendor and CRO management experience.
Strong working knowledge of ICH-GCP guidelines and clinical trial regulations.
Excellent organizational, problem-solving, and time management skills, with strong attention to detail.
Strong written and verbal communication skills with a collaborative, team-oriented approach.
Comfortable in a fast-paced, dynamic environment; a proactive, roll-up-your-sleeves mindset.
Legally authorized to work in the United States.

Responsibilities

Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
Assist with oversight of CRO and vendor set-up, liaising with CROs to ensure timely study initiation.
Review site-level regulatory documents (e.g., Informed Consent Forms, essential documents) and escalate to appropriate stakeholders as needed.
Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
Proactively identify potential operational challenges and, in partnership with senior team members, propose mitigation plans to keep study execution on track.
Assist with review of protocols, master template informed consent forms, case report forms, and other clinical study documents as needed.
Monitor study performance metrics, timelines, and deliverables, and review CRO trip reports for trends and quality issues.
Track study budgets and vendor invoices/change orders in partnership with Clinical Operations and Finance, flagging discrepancies as needed.
Help maintain timely and accurate study registration and updates on ClinicalTrials.gov and other applicable registries.
Coordinate Clinical Trial Team meetings and drive action item follow-up.
Maintain clinical operations trackers, databases, and document repositories.
Provide regular study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.