Clinical Development Medical Director - Cardiovascular

GSK • Upper Providence, PA

4d • $222,750 - $371,250 • Hybrid

About The Position

GSK is seeking an experienced Medical Director in Clinical Development to provide clinical and scientific leadership for cardiovascular clinical and translational studies and asset-level programs within its Respiratory, Immunology & Inflammation Research Unit. The role contributes to assessing mechanisms and targets, target validation, life-cycle expansion, and innovative clinical development opportunities. It works cross-functionally to develop and execute clinical development plans and to advance foundational and real-world evidence, translational research, and biomarker capabilities.

The position provides clinical oversight across development programs, from early development and potentially into later stages. It supports evidence-generation strategy, study design and delivery, regulatory interactions, participant safety, and medical governance. The role leads a Clinical Matrix Team for a program and serves as a clinical point of contact for internal and external stakeholders, including regulators, investigators, and key opinion leaders. The role is hybrid, with at least two on-site days per week at a posted location and remote work available on other days. For candidates at Stevenage, the role will initially be based there, with a planned office relocation to Cambridge, UK, proposed by early 2029.

Requirements

• Medical degree.
• Completion of formal postgraduate clinical training, clinical residency, or specialty training, such as in Internal Medicine or Pathology.
• Demonstrated experience in clinical-trial conduct, including medical monitoring, safety review, and clinical-data interpretation.
• Strong working knowledge of clinical-development processes, including GCP, ICH guidelines, and global regulatory frameworks.
• Ability to apply clinical judgment to study design, patient safety, and real-time medical decision-making within a structured clinical-development framework.
• Experience working effectively in cross-functional matrix teams in a pharmaceutical, biotechnology, or academic clinical-trial environment.
• Strong scientific communication skills and ability to translate clinical data into clear insights for internal and external audiences.

Nice To Haves

• Advanced specialty training, fellowship, or equivalent higher-level qualification leading to formal recognition as a medical specialist.
• Pharmaceutical or biotechnology clinical-development experience, particularly across early-phase studies.
• Clinical experience in a relevant specialty or therapeutic area, with direct exposure to clinical research or drug development in industry or postgraduate work.
• Knowledge of cardiovascular research priorities, public-health needs, competitor landscape, clinical-practice trends, and evolving treatment guidelines.
• Knowledge and experience executing clinical or translational studies, generating and analyzing human translational data, and conducting preclinical biological experiments in relevant model systems.
• Experience working with global regulatory agencies and managing global clinical trials in a relevant disease area.
• Prior contribution to regulatory interactions, such as IND submissions, scientific advice, or NDA/MAA filings.
• Experience engaging Key External Experts, investigators, and scientific collaborators in relevant disease areas.
• Demonstrated ability to collaborate in cross-functional teams and matrix environments to design and execute trials to regulatory standards.
• Experience contributing to IND/CTA, NDA, BLA, or MAA submissions.

Responsibilities

• Align translational and clinical plans and study designs with project strategies, supporting quality design and execution of clinical development plans.
• Develop sections of core regulatory documents.
• Generate evidence to assess a target’s potential efficacy, safety profile, differentiation, and path to becoming a medicine of value to patients.
• Define and deliver the clinical pillars of the translational table.
• Deliver clinical development and study timelines and endpoints, including pharmacology, mechanism, and clinical efficacy endpoints that support decision points and Go/No Go criteria.
• Maintain relationships with counterparts in Biology, Translational Sciences, Commercial, Regulatory, Clinical Operations, Market Access, Medical Affairs, and Statistics.
• Contribute to implementation of strategic and organizational initiatives in Clinical Development.
• Support and oversee R&D evidence-generation strategy, plans, and activities to protect patient safety and support timely, complete study delivery.
• Contribute to indication planning and deliverables such as early medicine profiles, target validation, translational plans, and candidate selection.
• Design clinical development plans, study protocols, and associated documents across development phases, incorporating relevant stakeholder input.
• Provide clinical expertise for regulatory interactions and documents, including briefings, presentations, and responses to questions.
• Provide medical monitoring and safety oversight of study participants on behalf of the Sponsor with the Pharmacovigilance Physician.
• Ensure scientific integrity and overall study-subject safety through medical governance across the project.
• Lead the Clinical Matrix Team for a program and represent it at relevant development-team or clinical-study forums.
• Lead end-to-end clinical development strategy for early programs and potentially contribute to later stages.
• Serve as the primary clinical contact for an early-development investigational agent or clinical study with internal and external stakeholders, regulatory agencies, key opinion leaders, investigators, and internal review boards.
• Assist with clinical evaluation of business-development opportunities.
• Monitor research advances, trial methodologies, the competitive environment, and regulatory developments in the relevant disease area.
• Identify opportunities for projects to deliver substantial patient benefit beyond existing approaches.
• Integrate cross-disciplinary input into clinical components of the Medicine Profile.
• Contribute to resolving study and clinical-development challenges and influence stakeholders across project and organizational levels.
• Use learning and digital tools to develop innovative scientific and technical approaches and encourage improvement and innovation in others.
• Influence and inspire others, tailor communications to audiences, build trust, manage conflicts, and negotiate mutually acceptable solutions.
• Apply enterprise-wide and strategic thinking, evaluate complex or incomplete information, anticipate risks, and make informed decisions in changing environments.

Benefits

• Annual bonus.
• Eligibility to participate in a share-based long-term incentive program, depending on role level.
• Health care and other insurance benefits for employees and family.
• Retirement benefits.
• Paid holidays and vacation.
• Paid caregiver, parental, and medical leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree