Faculty Position: Cancer In Vivo Gene Editing Investigators

Mayo Clinic • Jacksonville, FL

1d • Hybrid

About The Position

The Mayo Clinic Comprehensive Cancer Center (MCCCC) enterprise sites in Jacksonville, Florida and Rochester, Minnesota invite applications for open-rank faculty positions for innovative and accomplished Cancer In Vivo Gene Editing Investigators (Physicians and Scientists) to expand in vivo gene editing efforts in the Mayo Clinic In Vivo Human Gene Editing Program (Precision Genomics: Interventional Therapeutics: PG:IT) and the Mayo Clinic Comprehensive Cancer Center’s Programs in Cell Therapy Discovery and Translational Science. These reflect Mayo Clinic and Mayo Clinic Comprehensive Cancer Center’s commitment to accelerating the next generation of engineered cell therapies and to advancing curative treatments for cancer and other diseases. We seek exceptional investigators (scientists and physicians) with expertise in in vivo genome engineering and gene editing technologies (e.g., CRISPR/Cas systems, base editing, prime editing, epigenome editing, RNA editing, synthetic gene circuits, or related platforms) applied to human cells for ultimate therapeutic development and intervention. Successful candidates will have the opportunity to play a central role in advancing a rapidly growing, multidisciplinary cell therapy program focused on discovery science, translational innovation, and clinical impact. A key component of this role will be close collaboration with established CAR-T and immune cell therapy scientists, leveraging advanced genetic editing strategies to enhance persistence, safety, resistance to exhaustion, efficacy, tumor microenvironment adaptation, and manufacturability. While the successful candidates will focus on applications in cancer, they will have the opportunity to work in oncology and non-oncology indications across the Mayo Clinic enterprise to develop novel gene-engineered approaches that expand the therapeutic reach of cellular therapies beyond cancer, including autoimmune, inflammatory, genetic, and other degenerative disorders.

Requirements

• Hold a doctoral degree (Ph.D., M.D., M.D./Ph.D., Sc.D., or equivalent) in genetics, molecular biology, immunology, biomedical engineering, or a related discipline.
• A strong record of high-impact, peer-reviewed publications in genome editing, immune engineering, or related fields.
• Sustained extramural funding appropriate to academic rank (NIH K award or equivalent for Assistant Professor; R01-level funding or equivalent for Associate Professor or higher).
• Experience collaborating across disciplines, particularly with immunotherapy or CAR-T research programs.
• Evidence of scientific leadership and the ability to build and participate in collaborative, multidisciplinary research programs.
• A demonstrated commitment to mentorship, education, and fostering an inclusive academic culture.

Responsibilities

• Provide scientific expertise and have the opportunity for leadership roles in genome engineering strategies.
• Partner closely with CAR-T investigators and translational immunotherapy teams to develop next-generation engineered immune cell platforms.
• Develop innovative gene editing solutions to improve efficacy, durability, safety switches, multiplex editing strategies, and precision targeting in both malignant and non-malignant disease settings.
• Build scalable and clinically translatable genetic engineering pipelines that accelerate progression from discovery to early-phase clinical trials.
• Contribute to the strategic growth and national visibility of the Mayo Clinic PG:IT Program and Mayo Clinic Comprehensive Cancer Center’s Cell Therapy Programs.
• Mentor trainees, junior faculty, and research staff within a collaborative and inclusive academic environment.
• Participate in institutional initiatives aligned with Mayo Clinic and Mayo Clinic Comprehensive Cance Center’s vision to Cure, Connect, and Transform healthcare through transformative science.
• Integrate advanced genome engineering technologies into existing and emerging cell therapy platforms, enabling novel approaches to immune cell engineering, stem cell modification, in vivo gene editing strategies, and precision genome correction programs.

Benefits

• Competitive startup and sustained institutional support
• Investment in team science and program-building initiatives
• Access to a $1B+ annual research enterprise
• Infrastructure for IND-enabling studies and early-phase clinical trials
• Exceptional benefits, including retirement and pension programs
• A culture that values innovation, inclusion, and transdisciplinary collaboration

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree