Biomedical Technician - Genomics Core

Cedars-Sinai Medical Center•Beverly Hills, CA

5d•Onsite

About The Position

The Applied Genomics, Computation & Translational Core (AGCT) is seeking a Biomedical Technician to join their team. This role involves performing laboratory benchwork strictly according to Standard Operating Procedures (SOPs) with accurate documentation and a theoretical understanding of the assays used. The technician will be responsible for quality control of RNA and DNA samples, understanding sample quality nuances, and contributing to project success through effective communication and attention to detail. They will work with state-of-the-art technologies, including next-generation sequencing library preparation and sequencing. The AGCT Core is an automated, high-throughput genomics facility specializing in single-cell and spatial omics, utilizing platforms such as 10x Genomics, Parse Biosciences, Scale Biosciences, Illumina, Singular Genomics, Bruker CosMX SMI, and Oxford Nanopore Technologies. They offer comprehensive support from sample preparation and library construction to diverse sequencing applications and bioinformatics analysis, including custom computational solutions and results interpretation.

Requirements

Associate Degree or College Diploma in Biology, Biochemistry, or a related scientific or engineering discipline.
Minimum of one (1) year of hands-on experience in a laboratory or biotechnology environment.
Demonstrated experience working with biomedical equipment, including routine maintenance, calibration, troubleshooting, and/or performance testing.

Nice To Haves

Experience with single-cell and spatial assay technologies.
Familiarity with techniques such as single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, multiplex imaging, or other high-dimensional molecular profiling platforms.
Working knowledge of sample preparation workflows, library preparation, quality control metrics, and data generation associated with next-generation sequencing or imaging-based assays.
Experience handling complex biological specimens and maintaining data integrity in high-throughput experimental environments.
Bachelor’s Degree in Biology, Biochemistry, or a related science or engineering field.

Responsibilities

Performs a variety of project-specific process development tasks for multiple clients following standard operating procedures (SOPs).
Maintains good documentation in laboratory notebooks, data record/transfer, SOPs, and batch records.
Drafts standard operating procedures and maintains computer database.
Verifies samples received, logs samples into systems, and may transport to appropriate environment within the facility for storage following SOPs.
Performs lab maintenance duties, including glassware cleaning and sterilization.
Maintains lab equipment and related records.
Prepares cGMP production room, maintains material inventories, and places orders for equipment and supplies.
Assists in the operation of specialized equipment and machinery.
Ensures all activities comply with regulatory guidelines and safety standards, as appropriate.
Construction of next generation sequencing libraries for bulk cell, single cell, and/or spatial omics using commercially available reagent kits.
Illumina short-read sequencing and/or Oxford Nanopore Technologies long-read sequencing of NGS libraries.
DNA/RNA QC via fluorescent quantification and automated electrophoresis.
Operation of state-of-the-art genomics equipment including NGS sequencers, automated liquid handlers, and tissue imagers, as well as standard laboratory equipment such as thermal cyclers, centrifuges, and qPCR machines.
Mathematical calculations, including fold dilution, normalization, and conversions.
Understand, analyze, and interpret DNA/RNA/NGS library/sequencing QC results.
Liaise with post-doctoral, doctoral, and staff researchers, clinical investigators, and principal investigators to provide quality customer service.
Handle multiple demands and/or manage complex and competing priorities, pivoting as needed based on current needs in a dynamic environment.
Apply advanced knowledge of science/learning/specialized intellectual instructions to analyze, interpret, or make deductions from varying facts or circumstances.
Provide and/or support a level of work excellence and accuracy; recognize and address flaws or errors that others may overlook.
Regular oral and written communication with team members and team lead.
Accurate and detailed electronic documentation of work performed and results obtained.
Work independently as part of a team under direct supervision of a team lead.
Observe and comply with all safety standards and procedures.