Biomedical Technician - Genomics Core

Cedars-Sinai•West Hollywood, CA

6d•$31 - $48•Onsite

About The Position

The Applied Genomics, Computation & Translational Core is looking for a Biomedical Technician to join the team! This role contributes to the laboratory sciences team of the lab. They work independently as part of a team under direct supervision of a team lead. The Biomedical Technician is responsible for performing laboratory benchwork strictly according to Standard Operating Procedures with accurate documentation and a theoretical understanding of assays utilized. They perform quality control on RNA and DNA samples, understanding the nuances of sample quality and qualifications. The Biomedical Technician contributes to the success of projects by providing good oral and written communication, documentation, and attentiveness to detail. They work with state-of-the-art technologies and instruments, performing next generation sequencing library preparation and sequencing.

Requirements

Candidates with experience in single-cell and spatial assay technologies are highly desirable.
Familiarity with techniques such as single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, multiplex imaging, and other high-dimensional molecular profiling platforms.
A working knowledge of sample preparation workflows, library preparation, quality control metrics, and data generation associated with next-generation sequencing or imaging-based assays is strongly valued.
Experience handling complex biological specimens and maintaining rigorous data integrity within high-throughput experimental environments is also preferred.

Responsibilities

Performs a variety of project-specific process development tasks for multiple clients following standard operating procedures (SOPs).
Maintains good documentation in laboratory notebooks, data record/transfer, SOPs, and batch records.
Drafts standard operating procedures and maintains computer database.
Verifies samples received, logs samples into systems, and may transport to appropriate environment within the facility for storage following SOPs.
Performs lab maintenance duties, including glassware cleaning and sterilization.
Maintains lab equipment and related records.
Prepares cGMP production room, maintains material inventories, and places orders for equipment and supplies.
Assists in the operation of specialized equipment and machinery.
Ensures all activities comply with regulatory guidelines and safety standards, as appropriate.
Construction of next generation sequencing libraries for bulk cell, single cell, and/or spatial omics using commercially available reagent kits.
Illumina short-read sequencing and/or Oxford Nanopore Technologies long-read sequencing of NGS libraries.
DNA/RNA QC via fluorescent quantification and automated electrophoresis.
Operation of state-of-the-art genomics equipment including NGS sequencers, automated liquid handlers, and tissue imagers, as well as standard laboratory equipment such as thermal cyclers, centrifuges, and qPCR machines.
Mathematical calculations, including fold dilution, normalization, and conversions.
Understand, analyze, and interpret DNA/RNA/NGS library/sequencing QC results.
Liaise with post-doctoral, doctoral, and staff researchers, clinical investigators, and principal investigators to provide quality customer service.
Handle multiple demands and/or manage complex and competing priorities, pivoting as needed based on current needs in a dynamic environment.
Apply advanced knowledge of science/learning/specialized intellectual instructions to analyze, interpret, or make deductions from varying facts or circumstances.
Provide and/or support a level of work excellence and accuracy; recognize and address flaws or errors that others may overlook.
Regular oral and written communication with team members and team lead.
Accurate and detailed electronic documentation of work performed and results obtained.
Work independently as part of a team under direct supervision of a team lead.
Observe and comply with all safety standards and procedures.