Associate Staff Scientist (CUSToM) Immunoengineering/ Organoid generation

Cincinnati Children's•Orleans, MA

18d•Onsite

About The Position

Are you enthusiastic about working on Organoids at the interface of academic research and industry applications? Do you want to be part of a great interdisciplinary, international team? The Accelerator Lab at the Center for Stem Cells and Organoid Medicine (CuSTOM) at Cincinnati Children’s Hospital is seeking an Associate Staff Scientist with a focus on immunocompetent Organoid models. This is a rare opportunity to join CuSTOM at Cincinnati Children’s, where we revolutionize drug discovery and development, personalized medicine, and improve patient care using advances in developmental biology and stem cell technologies. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. There's no better place to make a difference in medicine, patients, and society. Established in 2019, CuSTOM Accelerator is a state-of-the-art laboratory focused on addressing major challenges posed to bench-to-bedside translation of stem cell research. At CuSTOM Accelerator, we work at the intersection of academia and industry to develop organoid-based platforms that provide an unprecedented opportunity to bridge preclinical and clinical trials, revolutionizing personalized medicine and improving patient care. Your tasks: · Establishing and applying organoid-based HTS/HSC platforms · Isolation, culture, and characterization of immune cells · Planning, conducting, and analyzing assays using organoid models · Evaluation of immune phenotypes in the platform · Presentation and publication of research results Candidate profile: · Completed PhD in natural sciences or engineering · Previous postdoctoral experience in academic or industry research is an advantage · Comprehensive practical experience in (primary, stem cell) cell culture, organoids, or organs-on-chips, and microscopy · In-depth knowledge with a focus on immunoengineering · Experience with stem cells and organoids is desirable · Willingness to engage in interdisciplinary research activities (life science and engineering) · Very good knowledge of English as well as a structured, independent way of working What we offer: · The opportunity to work within an exciting multidisciplinary project and delve into highly innovative research topics · A highly motivated, competent, and multidisciplinary team with scientific and technical staff members · Excellent technical equipment and laboratory infrastructure · An exciting, varied, and innovative working environment and excellent technical equipment

Requirements

Completed PhD in natural sciences or engineering
Comprehensive practical experience in (primary, stem cell) cell culture, organoids, or organs-on-chips, and microscopy
In-depth knowledge with a focus on immunoengineering
Willingness to engage in interdisciplinary research activities (life science and engineering)
Very good knowledge of English as well as a structured, independent way of working
3+ years of work experience in a related job discipline

Nice To Haves

Previous postdoctoral experience in academic or industry research is an advantage
Experience with stem cells and organoids is desirable

Responsibilities

Conduct Research - Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques.
Design and perform experiments and record data according to research protocol.
Independently reproduce, evaluate, research and improve techniques currently used.
Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition.
Maintain accurate and detailed records of all laboratory work and experiments.
Develop, set-up and verify new procedures in the laboratory.
Standardize and establish new published procedures; evaluate innovative techniques.
Develop new assays and new protocols; design formats.
Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis.
Troubleshoot and correct erroneous results or problems with laboratory equipment.
Maintain and repair equipment; monitor proper use by personnel.
Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
Publish - Draft, write and edit scientific reports, papers, journal articles and abstracts.
Present at local, national and international scientific meetings.
Teamwork - Train and supervise the work of other laboratory personnel as appropriate.
Maintain an integral role in the laboratory's meetings, presentations and publications.
Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars.
Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
Financial Management - Assist in preparing, writing and maintaining fiscal budget.
Monitor expenditures and prepare capital expenditure requests.
Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
Leadership - May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction.
May provide input and feedback to managers on hiring decisions, professional development and performance management.