Associate Scientist in Protein Mass Spectrometry

Pfizer • Groton, CT

1d • $60,200 - $100,400 • Onsite

About The Position

Pfizer is hiring an Associate Scientist in Protein Mass Spectrometry within the Structural Analytical and Molecular Sciences (SAMS) department in Groton, Connecticut. The role supports experimental protein characterization, with a focus on learning and deploying native mass spectrometry (MS) and other structural MS methods to characterize protein-ligand interactions. The successful candidate will handle recombinant protein samples, contribute to binding studies, and support open-access MS instrumentation and users.

The position is part of an integrated, collaborative team with expertise in molecular biology, protein biochemistry, biophysics, and structural biology. The team works with Pfizer drug discovery groups across therapeutic areas, providing molecular and structural insights into targets, lead molecules, and protein-ligand interactions. The candidate will contribute bench-level scientific work, communicate experimental findings, and collaborate across discovery projects.

Requirements

• Bachelor of Science in chemistry, biochemistry, biophysics, molecular biology, or a related field.
• Approximately 1–3 years of relevant laboratory experience.
• Skill and familiarity in handling and manipulating recombinant protein samples.
• Ability to multitask and balance parallel activities.
• Ability to troubleshoot scientific and technical challenges and contribute to their resolution.
• Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and productivity.
• Curiosity about how AI tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use.
• Permanent work authorization in the United States; U.S. work visa sponsorship is not available.

Nice To Haves

• Expertise in biochemistry and experimental protein characterization.
• Experience with native MS, nanoelectrospray applications, or MS characterization of large molecules.
• Previous experience with mass spectrometry instrumentation and data analysis.

Responsibilities

• Learn and deploy native MS and other structural MS methods to characterize protein-ligand interactions.
• Handle and manipulate protein samples for quantitative and qualitative binding studies.
• Support and maintain open-access MS systems for a suite of users.
• Assist with data collection and processing as needed.
• Participate in multidisciplinary teams supporting discovery projects across diverse disease areas.
• Communicate experimental work and analysis effectively in oral and written form.
• Complete timely laboratory notebook entries and review completed experiments.

Benefits

• 401(k) plan with Pfizer matching contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver, parental, and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Participation in Pfizer’s Global Performance Plan, with a bonus target of 7.5% of base salary.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level