Principal Scientist, Mass Spectrometry

BeiGene•San Carlos, CA

2d•$165,300 - $206,600•Onsite

About The Position

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles: Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision. Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs. As a Principal Scientist at BeOne Institute, you will play a key role in conceptualizing, enabling, and driving cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches that expand the frontiers of drug discovery. Working at the interface of biology, chemistry, and technology development, you will help define new ways to interrogate complex biological systems and generate actionable insights that can be translated into transformative medicines. This is a rare opportunity to pursue bold ideas and translate them into real medicines!

Requirements

Proficiency with mass spectrometry data acquisition, processing, and analysis software.
Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets.
Experience with software and tools for MS-based screening and assay development.
Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.
Deep expertise in mass spectrometry, with demonstrated hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.
Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows.
Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays.
Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets
Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities
Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches
Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
Be able to work on-site in San Carlos, CA

Nice To Haves

Experience with Orbitrap systems (Astral a plus) and Agilent Q-TOFs strongly preferred.
Knowledge of cancer pathways.
Experience with ASMS and APMS workflows (in a drug discovery setting a plus).

Responsibilities

Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities.
Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.
Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.
Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.
Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.
Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.
Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.
Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.