Associate Scientist

Xaira Therapeutics•South San Francisco, CA

About The Position

We are seeking an Associate Scientist to join our High-Throughput (HTP) team to support the discovery and development of innovative protein therapeutics. This role focuses on the design and execution of HTP expression, purification, and characterization campaigns. You will work at the interface of biochemistry and automation, collaborating closely with our robotics and data teams to advance candidate molecules from in silico design to physical validation. The successful candidate works effectively both independently and as part of cross-functional teams. Experience collaborating with discovery, process development, and analytical departments is highly desirable. We require an adaptable scientist with strong communication skills and the ability to present data across team and departmental levels. You should excel in fast-paced environments, managing multiple responsibilities and shifting priorities. You are expected to work effectively both independently and as part of a team to drive complex projects forward. This is a hands-on role suited for a scientist who is passionate about advancing drug discovery and development through innovation and scientific rigor.

Requirements

B.S. (6+ years) or M.S. (6+ years) in a relevant scientific discipline; industrial experience preferred.
Proven expertise in high-throughput (HTP) protein production, with a specific focus on cell-free protein expression (CFPE) and/or mammalian transient expression systems.
Understanding of the biophysics of protein-protein interactions, protein chemistry, experience in the molecular biology and biophysical techniques essential for protein work is required.
Demonstrated hands-on experience with high-throughput (96/384-well) expression and purification workflows.
Proven track record of independent project management and cross-functional collaboration.
Dedicated to inclusive leadership and maintaining a respectful, diverse team environment.

Nice To Haves

PhD (2+ years)
The experience and flexibility to work on upstream medium scale expression and downstream purification is a plus.

Responsibilities

High throughput protein expression, purification and characterization from multiple systems including cell free systems and mammalian is the primary responsibility.
Drive team throughput and data quality by developing novel strategies for parallel protein processing.
Optimizing expression and purification workflows and conducting quality control and functional assays for proteins used in therapeutic development and in silico design.
Perform analytical characterization of purified proteins using HPLC, CE-SDS, and icIEF to ensure high-quality candidates for therapeutic development.