Associate Scientist, Synthesis Process Development
About The Position
Bristol Myers Squibb is seeking a motivated and detail-oriented Associate Scientist to join our RNA Synthesis Process Development team in Cambridge, MA. The RNA PD team works to develop, characterize, and implement robust preclinical and clinical manufacturing processes to support Bristol Myers Squibb's exciting pipeline of products. This role is specifically focused on RNA synthesis process development, with responsibilities spanning early process development through clinical manufacturing support. This is an excellent opportunity for an early-career scientist to grow within a dynamic, fast-paced environment. The successful candidate will support planning and execution of laboratory studies and contribute to protocols, technical reports, and regulatory documentation under the guidance of senior team members.
Requirements
- BS with 3+ years of industry experience, or MS with 0–3+ years of relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline
- Hands-on experience with RNA synthesis techniques, specifically in vitro transcription
- Familiarity with analytical tools used to assess RNA quality, including gel electrophoresis, HPLC, or capillary electrophoresis
- Basic understanding of RNA purification unit operations
- Strong laboratory fundamentals and attention to detail; comfortable working with bench-top equipment including bioreactors, FPLCs, and UF/DF skids
- Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members
Nice To Haves
- Exposure to GMP principles or cGMP environments is a plus but not required
- Experience with design of experiments (DoE) or statistical analysis software is a plus
Responsibilities
- Execute hands-on laboratory experiments focused on RNA synthesis process development and scale-up from bench to pilot scale
- Design and perform experiments for optimization and characterization of in vitro transcription reactions using structured approaches (i.e. QbD principles, DoE)
- Support routine downstream purification unit operations (e.g. chromatography, UF/DF) and contribute to process optimization efforts that bridge synthesis and purification workflows
- Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early- to late-stage development activities
- Perform routine analytical testing to assess RNA purity, concentration and key quality attributes
- Analyze and interpret experimental results, present findings to senior scientists and project teams
- Collaborate with internal R&D, analytical development, and manufacturing to advance BMS's RNA pipeline
- Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed
- Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards
Benefits
- Medical, pharmacy, dental, and vision care
- BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP)
- 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support
- flexible time off (unlimited, with manager approval, 11 paid national holidays)
- 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
- unlimited paid sick time
- up to 2 paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
- an annual Global Shutdown between Christmas and New Years Day
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Associate degree
