Associate Scientist II, RNA Synthesis

Alnylam Pharmaceuticals•Cambridge, MA

5d•$67,600 - $101,400•Onsite

About The Position

We are looking for a talented and highly motivated Associate Scientist II to join our RNA synthesis group and support our mission to deliver the next generation of RNAi-based medicines. The successful candidate will contribute to the purification and analysis of oligonucleotides in support of our growing RNAi drug development platform. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

Bachelor’s in Chemistry, Biochemistry, or a related field.
0-3 years of relevant work experience, preferably in an industrial setting.
Experience with instrumentation such as analytical and prep HPLC, LC-MS, UV-Vis spectrometry, etc. is required.
Ability to function within a highly interdisciplinary environment is a must.
Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.

Nice To Haves

Experience with solid-phase synthesis (oligonucleotides, peptides, etc) is preferred but a background in organic chemistry is sufficient.
Good understanding of chromatography and experience in developing methods (IEX/RP HPLC, LC-MS) is a plus.

Responsibilities

Purification and analysis of chemically modified oligonucleotides using automated platforms.
Utilize a various range of HPLC prep instruments to perform purification and desalting of the synthesized oligonucleotides.
Utilize analytical instrumentation such as UV-Vis spectroscopy, HPLC, and/or LC-MS for the analysis of both crude and purified synthetic products.
Effectively troubleshoot synthetic/process issues and independently find solutions.
Improve upon and/or develop new methods and automation for the downstream processing of synthetic oligonucleotides and their subsequent analysis/purification and annealing into siRNA duplexes.
Maintain clear, accurate, and timely experimental documentation.
Maintain and troubleshoot essential lab equipment, coordinating servicing and repairs as needed.
Analyze, interpret, and organize analytical data to present to team members.