Sr. Scientist, Pharmacometrics

Xyzagen•Pittsboro, NC

1d•$65,000 - $115,000•Hybrid

About The Position

Xyzagen (ZiZaGen) is seeking a recent graduate scientist with good problem-solving skills and strengths in quantitative analysis. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of pharmacokinetic and/or pharmacodynamic analyses. Successful candidates will possess a passion for drug development and pharmacometrics and be an adaptable problem solver with an optimistic attitude. Xyzagen is a contract research lab supporting pharmacokinetics, ADME and bioanalytical, pharmacology and nonGLP safety assessments in mice and rats. Xyzagen is also a drug development consultancy providing regulatory advice to clients in the nonclinical and clinical pharmacokinetic disciplines. Xyzagen has provided strategic advice to early NIH funded biotechs, small and mid-size pharma and venture capital firms. At Xyzagen, we accelerate medicines to patients by partnering with life science innovators. In the past 8 years, we have worked with over 100 different innovators worldwide and have helped in the approval of multiple new therapeutics by the FDA. Xyzagen also conducts its own research on Kv7 channel openers within the therapeutic areas of Neurology and Pain. Our strong team of scientists and subject matter experts enable our clients to have: Cost effective and informed decision-making, Faster study start up for in vivo pharmacokinetic and safety assessment studies in rodents, Wide range of contract research services to regulatory advice regarding pharmacokinetics of a client’s molecule and therapeutic program. Additionally, we are expanding our laboratory and office space from 5,000 to 11,000 sq ft to continue to provide a resource center for early innovators within the Life Science and Biotech communities.

Requirements

BS, MS, PhD, PharmD in Pharmaceutical Sciences, Bioengineering, Pharmacology, Statistics, Applied Mathematics, Medicine, or a related field.
Relevant years of industry experience will be considered alongside of educational degree. Academic research may be considered if deemed sufficiently aligned with the responsibilities of the role.
Demonstrated understanding experience in some or all of the following: nonclinical and clinical pharmacology study design, pharmacometrics, modeling and simulation.
Expertise in PK/PD modelling with strong quantitative skills applied to develop models with nonlinear behavior, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
Strong mathematical and statistical background and mathematical modeling quantitative skills applied to develop models with nonlinear behavior, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
Experience to Proficiency in PK/PD and statistical software (e.g., Phoenix, NLME, NONMEM, R, Prism).
Excellent writing and verbal presentation skills to internal and external audiences.
Strong communicator (written/oral) in client facing roles (presentation to clients and authoring of study reports).
Exceptional time management and self-motivation.

Nice To Haves

Experience with NIH or Department of Defense grants

Responsibilities

Supporting client projects building computational models describing biological response to a molecule following dosing.
Working on a variety of therapeutic indications from Ophthalmology through Respiratory, Pain and Neurology/Psychiatry with large and small molecules.
Being exposed to crafting regulatory documents, statistical analysis and study protocols for nonclinical studies and clinical trials.
Expanding their understanding of the pharmaceutical drug development process.
Gaining experiences applying pharmacometrics modeling concepts to a broad array of companies, molecular modalities, and therapeutic areas.
Developing communication skills as a pharmacology consultant by contribution in business development and client management initiatives.
Hands on pharmacometric modeling on client projects as a billable consultant.
May lead/coordinate company initiatives (e.g. IT, methodology, efficiency, automation, quality).
May act as the primary point of contact for clients and collaborate with the principal or senior consultant to grow business to match their interests.

Benefits

A competitive salary and meaningful equity compensation
Company-paid holidays (closed between Christmas and New Year’s)
Paid time off (2 weeks)
Medical
Dental
Vision
401(k) plan + Safe Harbor Match + Profit Sharing + Defined Benefit retirement plan
Flexible time off for personal business is not tracked
Ability to work from home when possible
Flexible schedule
Potential for relocation stipend for relevant expenses