Associate Scientist/Scientist I, LNP Formulations

Mirai Bio, Inc.•Cambridge, MA

16h•Onsite

About The Position

Mirai Bio is seeking a scientist to advance our lipid nanoparticle (LNP) delivery platform for nucleic acid therapeutics. Mirai Bio is seeking a highly talented and motivated individual to develop and optimize lipid nanoparticle (LNP) formulations. The successful candidate will contribute to both platform innovation and preclinical pipeline programs, working at the interface of formulation science, Chemistry, analytical characterization, and process development.

Requirements

Ph.D. and 0-1 years or 4+ years (M.Sc.) or 6+ years (B.Sc.) of relevant industry experience in LNP formulation optimizations and drug delivery with strong background in nucleic acid therapeutics and education in life sciences or engineering (Pharmaceutical Sciences, Biomedical Engineering, Biochemistry, etc)
Hands-on experience in nanoparticle or LNP formulation and characterization
Strong understanding of drug delivery systems, particularly for nucleic acid therapeutics
Experience with nanoparticle characterization techniques (e.g., DLS, zeta potential, fluorescence-based assays such as Ribogreen, chromatography)
Demonstrated ability to design, execute, and troubleshoot experiments independently
Strong data analysis, documentation, and communication skills

Nice To Haves

Familiarity with formulation process technologies (e.g., microfluidic mixers, pumping systems, TFF)
Experience with high-throughput formulation screening approaches
Knowledge of lipid chemistry, ionizable lipid design, or bioconjugation techniques
Experience supporting in vivo studies or translating formulations from research to preclinical scale

Responsibilities

Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery across early research and preclinical development stages
Develop and optimize formulation processes, including microfluidic mixing and scale-up approaches (e.g., TFF, ultrafiltration)
Screen and evaluate novel ionizable lipids and LNP compositions; analyze structure–function relationships to improve delivery performance
Troubleshoot formulation and process challenges to enhance robustness, reproducibility, and scalability
Generate high-quality, reproducible data and maintain thorough documentation in electronic lab notebooks
Prepare LNP formulations to support internal research and partner programs
Collaborate cross-functionally with analytical, translational, and Tech development teams to advance platform goals
Present data and insights clearly to internal teams and contribute to scientific discussions and decision-making