Associate Scientist / Scientist I, Functional Genomics

Vividion Therapeutics•San Diego, CA

2d•Onsite

About The Position

The successful candidate will be part of the Functional Genomics department, which is devoted to identifying and characterizing novel drug targets for cancer using our functional genomics platforms. This person will play an important role in advancing our discovery platform technology and small molecule pipeline. The candidate will assist in the design and implementation of experiments aimed at identifying and validating drug targets and defining drug or gene mechanism of action. The ideal candidate is a well-rounded molecular biologist with demonstrated experience in cancer or immunology drug discovery. This is a unique opportunity to be part of a growing team and make an impact on all aspects of the drug discovery and development process. We are looking for intrinsically motivated people who are driven to make a real difference in the lives of patients with cancer or immune-related disorders.

Requirements

BS in a relevant scientific field with at least 7 years of hands-on laboratory experience; MS with 5 years; or PhD with 0-2 years of experience; industry experience preferred
Experience working as part of a goal-oriented team
Demonstrated ability to work proficiently, maintain deadlines and think critically about technical aspects of experiments
Must be detail oriented and demonstrate excellent communication skills
Experience with molecular and cellular biology techniques such as cloning, PCR, qPCR, protein isolation, western blotting
Experience with multicolor flow cytometry
RNA/DNA isolation and sequencing
Extensive mammalian cell culture experience required
CRISPR, shRNA, and/or siRNA experience

Nice To Haves

Familiarity with genomic sequencing and functional genomic techniques
Experience working on small molecule drug discovery programs

Responsibilities

Independently conduct experiments to understand drug mechanism of action
Conduct large-scale mammalian cell culture experiments
Successfully deploy advanced CRISPR/Cas9 techniques to perturb the genome and transcriptome
Conduct large-scale mammalian cell culture genetic perturbation studies using advanced CRISPR/Cas9 techniques
Use molecular biology techniques to support target and hit validation
DNA isolation, library preparation and next-generation sequencing
Cell line engineering
Contribute to experimental design and planning
Perform and optimize cellular assays to support drug discovery efforts
Independently summarize, analyze and regularly present work internally
Maintain exceptional scientific records of projects and experiments