Associate Scientist, Product Biochemistry

Regeneron Pharmaceuticals•Tarrytown, GA

10d•$70,300 - $110,100•Onsite

About The Position

The Product Biochemistry group is seeking a highly motivated Associate Scientist to support the in-depth biochemical and biophysical characterization of biotherapeutic molecules. The successful candidate will contribute to method development, assay support, and technology innovation efforts that advance research, pre-clinical, and clinical programs. This role involves close collaboration with cross-functional teams and supports programs from early-stage research to post-commercial activities. This role will primarily focus on GxP characterization and stability testing of reference standards.

Requirements

Hands-on experience with general laboratory operations and data organization, working under managerial supervision.
Fundamental technical proficiency in analytical methodologies such as: Size Exclusion Chromatography (SEC), UV-Vis spectrophotometry, spectroscopic-based methods (i.e., CD and FT-IR)
Understanding of biochemical and biophysical characterization principles for proteins and/or oligonucleotides.
Strong organizational skills with the ability to prioritize multiple tasks while keeping up with proper documentation
Clear written and verbal communication skills; ability to work both independently and collaboratively.
Scientific curiosity, attention to detail, and a willingness to learn new techniques and technologies.

Nice To Haves

Experience with additional analytical platforms such as HPLC/UPLC, light scattering (e.g., SEC-MALS, DLS), CD spectroscopy, fluorescence, FT-IR, and DSF.
Exposure to analytical method development and assay optimization.
Familiarity with late-stage development, comparability, or regulatory-supporting studies.
Experience working in a GxP lab and following SOP’s.
Experience with writing technical documents (e.g., SOP’s).

Responsibilities

Perform biochemical and biophysical characterization experiments to assess quality attributes of protein- and/or oligonucleotide-based therapeutics using techniques such as capillary electrophoresis, size exclusion chromatography coupled to multi-angle light scattering (SEC-MALS), dynamic light scattering (DLS), fourier transform infrared spectroscopy (FT-IR), fluorescence spectroscopy, circular dichroism (CD), differential scanning fluorimetry (DSF), and general lab techniques (pH, analytical balance, sample preparation).
Develop, optimize, and run light scattering–based assays (e.g., SEC-MALS, DLS, and related methods) with manager guidance to support molecule characterization and method qualification.
Analyze and interpret experimental data; identify trends and communicate key findings to project teams.
Accurately document all laboratory activities, data, and analyses in electronic laboratory notebooks (ELN) in accordance with established procedures.
Oversee and maintain GxP lab equipment in adherence with quality assurance (QA) standards.
Writing SOPs, summary of analysis (SoA’s), reports and recording information in a GxP controlled environment
Prepare clear, well-organized summaries of results (figures, tables, graphs) for presentations, reports, and regulatory-supporting documentation.
Present experimental results at group, departmental, and cross-functional meetings.
Maintain, troubleshoot, and operate essential laboratory instrumentation; ensure readiness of equipment and supplies.
Follow laboratory safety practices and contribute to an organized, compliant lab environment.