Associate Scientist II, Biology

Alnylam Pharmaceuticals•,

3d•$67,600 - $101,400•Onsite

About The Position

We are seeking a talented candidate to fill an Associate Scientist II position within Alnylam’s Research department. This position is an opportunity to potentially see one’s work progress from the bench to the clinic and positively impact patients’ lives. The successful candidate will support development of current therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a variety of novel indications and support their entry into the clinic. The successful candidate will have background in biological sciences and be technically skilled in basic laboratory techniques. Responsibilities will include designing, developing, and executing studies in rodent disease models, evaluation of small interfering RNAs (siRNAs) in wild-type animals, and conducting the associated in vitro molecular-based assays such as transcript and protein quantitation. Collaborative curiosity, passion for science, and a desire to learn new techniques are a must.

Requirements

Bachelors degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, Genetics with 1-3 years relevant experience or a Masters degree with 1 year of relevant experience
Proficiency in RNA/DNA/protein analysis techniques, including RNA isolation, ELISA, western blotting and RT-qPCR
Cell/tissue culture experience
Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)
Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
Must be flexible, open to new tasks and challenges, and able to work on tight deadlines
Proven ability to work in a team environment and across functional areas

Nice To Haves

Basic rodent in vivo skills is a plus
Experience setting up rodent disease models is a plus

Responsibilities

Contribute to study design and execution of studies to characterize compounds for RNAi therapeutic programs, including rodent disease models (or other preclinical models)
Develop and conduct assays such as qPCR, western blot, and ELISA, that support in vivo and in vitro studies
Perform in vitro and cell-based assays to characterize drug activity or mechanism of action
Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies
Analyze and interpret the data
Prepare clearly articulated experimental reports and data presentations
Prepare and develop protocols and methodologies
Present data to groups within and outside of Research