Associate Scientist, Compound Management, Cell Screening & NGS

Korro Bio•Cambridge, MA

13h

About The Position

Korro Bio is seeking a passionate, driven, and creative Associate Scientist to join our oligonucleotide compound management team and work with an enthusiastic team of highly skilled scientists in a dynamic, growing company. The successful candidate will be responsible for handling, characterization, automation, storage and distribution of oligonucleotide compounds and work closely with cross functional team to advance our RNA editing drug discovery programs. The candidate will also be responsible for quantifying, performing purity analysis via HPLC/LCMS, and documenting results. The candidate will prepare samples and distribution of information to the downstream assay teams and pipelines. Additional responsibilities include cell screening and NGS work. Candidate must express a high attention to detail, be comfortable multitasking, oversee day to day operations and ability to function in an interdisciplinary and fast-paced startup environment.

Requirements

MS with 2+ years or BS with 4+ years of experience in molecular biology, analytical chemistry, cell biology, or a related field
Experience with nucleic acids and analytical chemistry: UV spectrophotometry, HPLC, LCMS, and gel electrophoresis
Experience with high-throughput cell-based assays and automated liquid handling workflows
Experience with NGS assays (amplicon-seq, RNA-seq), including primer design, library preparation, quantification, and data QC; hands-on experience with Illumina platforms highly preferred
Demonstrated proficiency in core molecular biology techniques: RNA/DNA isolation, transfection, PCR/qPCR
High attention to detail with the ability to accurately manage large compound sets and complex workflows
Strong troubleshooting skills and ability to propose and implement solutions independently
High degree of flexibility and self-motivation in a fast-paced environment, with the ability to prioritize and meet deadlines
Excellent interpersonal, written, and verbal communication skills

Nice To Haves

Experience with LIMS (e.g., Benchling), ELN, and project management tools (e.g., Jira/Confluence) a plus

Responsibilities

Oligonucleotide compound management and preparation of samples for biological screening, including manually and via automated liquid handlers (e.g., Hamilton, Tecan, Viaflo96/384, Tempest)
Analysis and formulation of test articles for in vitro and in vivo studies; receive, track, and maintain physical and virtual inventory of test articles, formulations, and components
Quantification of oligonucleotide compounds and formulated complexes via Mass Spec, UV spectrophotometry, and gel electrophoresis; purity analysis via analytical HPLC and LCMS, including method development and troubleshooting
Perform duplex & triplex annealing of oligonucleotides and Tm analysis
Independently design and execute high-throughput cell-based assays (96/384-well formats) to support oligonucleotide platform and portfolio projects, including cell culture, transfection, PCR/qPCR, and RNA/DNA isolation
Perform amplicon-seq and RNA-seq library preparation and QC; operate and maintain NGS platforms (e.g., Illumina MiSeq i100) and associated equipment (Qubit, TapeStation, Fragment Analyzer)
Troubleshoot HTS assays, library preparation, and sequencing workflows as needed
Analyze, report, and present HTS-NGS and analytical chemistry data in a team setting; collaborate cross-functionally to support lead discovery and project execution
Accurately document experiments, protocols, and results in an electronic lab notebook (ELN); support operational tasks including inventory management and process improvement