Associate Scientist, Biology
About The Position
The Oncology department at Gilead Sciences is seeking an experienced and motivated Associate Scientist/ Senior associate Scientist with exceptional technical skills to support research programs focused on the discovery and development of novel therapies that mobilize the immune response against cancer. The successful candidate will be instrumental in conducting experiments and help develop novel assays to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors. Our highly diverse, collaborative, and interdisciplinary research teams utilize state-of-the-art technologies and innovative methodologies to advance novel immuno-oncology therapies into the clinic. The position has ample opportunities for career growth through acquisition of new skills, experiences, and professional relationships in an inclusive, fast-paced, and resource-rich environment. The successful candidate will contribute to therapeutic candidate characterization in immune cell-mediated killing assays, new admixed immune cells / cancer cells assay development, mechanism of action studies, and flow cytometry-based immune profiling/phenotyping studies in vitro and from dissociated mouse tumor samples.
Requirements
- 4+ Years with BS
- 2+ Years with MS
- Industry research experience preferred (BS +4 years OR MS +2 years) in cancer immunology or related field with a record of achievements (publications)
- Great attention to detail with excellent organizational and record keeping skills
- Strong motivation, independence, and ability to think critically and act creatively to resolve problems
- Excellent communication and interpersonal skills and ability to integrate into a high-paced multidisciplinary environment
- Experience in running and developing cell-based assays (T cell-mediated killing assays, Jurkat reporter assays)
- Experience in conducting and optimizing cell-based assays, as well as performing studies to assess immune responses in human and animal models (including whole blood, PBMCs, and various primary cell subsets).
- Experience with gene knockdown (RNAi), knockout (CRISPR/Cas9), and overexpression techniques (transfection, viral transduction)
- Hands-on experience in general molecular biology methods, including basic flow cytometry, western blot, ELISA/Luminex/MSD
Responsibilities
- Independently execute and analyze studies that support the pre-clinical characterization of immune engager candidates, with contributions to multiple projects
- Support target validation efforts through characterization and generation of cellular models
- Help develop novel, complex cell biology assays to model tumor biology
- Explore mechanism of action of immune engager molecules by functional and Flow cytometry-based characterization of molecules
- Prepare and present findings to the team and at department-wide meetings
- Contribute figures to research reports, manuscripts, INDs, and patent filings
Benefits
- company-sponsored medical, dental, vision, and life insurance plans
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
