Associate Principal Scientist - Process Engineer
About The Position
AstraZeneca is a global, science-led biopharmaceutical company. Pharmaceutical Technology & Development (PT&D) is responsible for turning brilliant science into real medicines, covering the entire value chain from early toxicology and clinical supplies to technology that enables robust commercial manufacture. Global Product Development (GPD) leads the late-stage design and development of drug products across a range of dosage forms, developing the formulation, manufacturing process, and scientific understanding needed to scale, launch, and sustain new medicines. The Associate Principal Scientist in Process Engineering will play a key role in leading the process engineering aspects of projects in late-stage development for oral solid dosage forms, including Continuous Direct Compression. This role involves collaborating in multidisciplinary teams with engineers and pharmaceutical scientists to advance life-changing medicines. The scientist will be a recognized problem solver and team player, passionate about ensuring product robustness through well-understood, controlled, and capable manufacturing processes.
Requirements
- Bachelors Degree in Related Discipline (e.g - Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences) with 5 - 10 years of relevant industrial experience.
- Experience in oral solid dose development.
- Experience in late-stage product development, technology transfer, scale-up and process validation.
- Fundamental understanding of control strategy and risk management.
- Basic understanding of predictive science, artificial intelligence, modelling and simulation.
- Excellent communication and collaboration skills
Nice To Haves
- Masters or PhD in Life Sciences (e.g. - Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences).
- Experience with a range of unit operations e.g. continuous manufacturing, granulation, compression, coating.
- Experience with regulatory authoring and defence.
- Experience with CMOs/CROs and outsourced development.
Responsibilities
- Lead engineering input for the design and development of robust manufacturing processes for oral solid dosage forms.
- Plan and execute lab-scale experiments to facilitate project decisions.
- Shape the scientific and technical direction of product development activities through process understanding and control.
- Define and optimize critical process parameters (CPPs) and integrate them into control strategies.
- Lead or contribute to technology transfer, risk assessment, process validation and scale-up.
- Apply modelling, simulation, digital twins and predictive tools to enhance process understanding.
- Solve key technical challenges with direct impact on current project delivery.
- Drive a culture of creativity, innovation and scientific excellence.
- Contribute to integrated drug product development plans within a multidisciplinary team.
Benefits
- Qualified retirement program [401(k) plan]
- Paid vacation and holidays
- Paid leaves
- Health benefits including medical, prescription drug, dental, and vision coverage
- Flexible employee benefits fund
- Holiday purchase
- Flexible time off
- Pension contributions
- Share Save Plans
- Performance recognition scheme
- Competitive, generous remuneration package
- Short-term incentive bonus opportunity
- Eligibility to participate in our equity-based long-term incentive program (salaried roles)
- Retirement contribution (hourly roles)
- Commission payment eligibility (sales roles)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
