Associate Manufacturing (Pilot Plant)

Amgen•West Greenwich, RI

6d•$70,985 - $96,039

About The Position

The Associate Manufacturing (Pilot Plant) role supports execution of cell culture, harvest, and purification process studies at the 500L scale. The position operates single-use bioreactors, centrifugation equipment, chromatography skids, and filtration systems. The Amgen Rhode Island AR6 Pilot Plant provides technical support for team supply, commercial process development, technology transfer, process characterization, and scale-up/scale-down activities. This is a day-shift position that includes off-shift and weekend coverage.

Requirements

Bachelor’s degree; OR an associate’s degree plus 6 months of biotechnology experience in manufacturing, engineering, or process development; OR a high school diploma/GED plus 2 years of biotechnology experience in manufacturing, engineering, or process development.

Nice To Haves

An established record of encouraging safety in a lab or manufacturing setting.
Experience performing bioprocess unit operations in cell culture and/or purification.
Knowledge of troubleshooting process equipment issues, including automation control strategies and utilities such as clean in place (CIP) and clean steam.
Experience operating Delta V control systems and developing methods on Cytiva purification systems using Unicorn.
Experience with data analysis and interpretation.
Experience collaborating with and across functional areas and sites.
Strong written and verbal communication skills and strong computer skills.
Experience leading Operational Excellence efforts to drive efficiency and safety.

Responsibilities

Aseptically maintain mammalian cell culture from vial thaw and flask passaging through bioreactor operations and harvest, including centrifugation, multistage clarification, and/or ATF filtration.
Perform protein purification through multistage chromatography and filtration systems, including IEX, affinity chromatography, and tangential flow filtration.
Set up and operate bioreactors and vessels, centrifugation and filtration harvest equipment, and downstream equipment including chromatography and UF/DF skids.
Perform bench-work studies such as titration and filtration.
Perform in-process sampling and monitoring.
Analyze in-process samples and perform routine analytical equipment maintenance.
Perform batch and filtration of media and buffers.
Perform new product introductions, technology transfer, and participate in equipment or experiment design.
Document experimental data in electronic lab notebooks in accordance with Good Laboratory Practices.
Perform general lab organization and cleaning.
Manage inventory, Operational Excellence initiatives, and preventative maintenance for systems and equipment.
Inform operational decision-making, troubleshooting, and investigative work.