Associate Engineer, RNA Starting Material MS&T

Sarepta Therapeutics•Andover, MA

1d•$62,000 - $77,500•Onsite

About The Position

The Associate Engineer, RNA Starting Material MS&T will work in a team focused on lab-scale organic synthesis, purification, analysis, and characterization of the nucleoside-based and lipid building blocks of Sarepta’s phosphorodiamidate morpholino oligomers (PMOs), next-generation PMO, and siRNA platforms. The role will involve both synthesis of reference markers/standards and participating in supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize and troubleshoot syntheses. The role will involve cross-functional training, regular interaction with Analytical/QC resources, and interpretation of HPLC, GC, KF, and NMR data. The position involves protocol and report writing and requires excellent organic chemistry and problem-solving skills.

Requirements

B.S. (required) in Chemical Engineering, Chemistry, or related discipline
0-2 years related experience
Technical competence in organic chemistry and familiarity with analyzing and interpreting data from GC, LC-MS, HPLC, NMR, and KF instrumentation.
Able to handle multi-task workload and perform effectively under deadlines
Effective written and verbal communication skills
Strong interpersonal skills and attention to detail are necessary
Candidates must be authorized to work in the U.S.

Nice To Haves

Experience running HPLC methods is strongly preferred.
May require <5% infrequent domestic and/or international travel

Responsibilities

Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers/standards.
Execute development studies either independently or as part of a team under supervision.
Assess scalability of proposed changes and execute experiments to mimic the impacts of operations at large scale.
Participate in the Technology Transfer of improved processes to manufacturing sites.
Cultivate a firm scientific understanding of Sarepta’s manufacturing processes to support process improvements, troubleshooting, and technology transfers.
Perform synthesis and purification (chromatography) of nucleoside analogs to support both production and development goals.
Contribute to collaborative efforts to characterize and manage the impurity profiles of intermediates.
Use scientific judgement to determine likely source and fate of newly identified impurities and design experiments to test hypotheses as part of a cross-functional team.
Data compilation, data interpretation, documentation of study results, and presentation of data and conclusions.
Participate in vendor update meetings and provide input on ongoing vendor production projects.