Associate Director Therapeutic Area Genetics (Immunology)

Regeneron Pharmaceuticals • Tarrytown, GA

6d • Onsite

About The Position

We are looking for an extremely talented Scientist to join our Immunology Therapeutic Area Genetics (TAG) team. Within the RGC, the Immunology TAG team is using large-scale human exome sequencing for discovery and validation of new therapeutic targets in autoimmune and other immune-mediated disease. You will be responsible for designing and executing studies integrating large scale human genetics and multidimensional omics datasets derived from RGC and public resources in the immunology space to identify new targets for inflammatory and auto-immune diseases and accelerate target transition to novel therapeutics. You will collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to catalyze therapeutic development for genetically-validated targets in immunologic diseases. This role will require 4 days per week onsite at our campus in Tarrytown, NY. This is not available as a fully remote / hybrid work. In this role, a typical day might include the following: Understand and leverage RGC and Regeneron datasets, external resources, and the scientific/medical literature to generate research questions and then generate relevant phenotypes from longitiudinal clinical data, design and execute genetic association studies, and perform integrative omics analyses to address these research questions Deploy computational methods to integrate genetic data with multiple omics data to more effectively identify/prioritize drug targets illuminated by genetic association data. Work closely with other members of the Immunology and other TAG teams, Analytic Genetics, Sequencing, and GIDE in cross-functional initiatives within the RGC and Regeneron. Collaboratively summarize insights of investigations into a variety of formats (e.g. documents, presentations, patent applications, publications, etc.) for audiences with broad bacgrounds. Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.

Requirements

• Bring innovative thinking to human genetics and epidemiological studies
• Experience leading complex human genetics research incorporating different analytic methods, phenotypes, and study designs.
• Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative and important research questions.
• Worked with multidisciplinary teams to characterize the functional consequences of discovered disease gene variants
• Understanding of drug development and clinical trial design and execution.
• PhD , MD preferred with 8+ years of experience in the use of WES/GWAS datasets, RNA-Seq, proteomics and other large-scale platforms for genomic/proteomics.
• Demonstrated expertise in immunobiology, genetics, and mechanisms; familiarity with large genetic studies that deliver novel genetic findings and medically relevant gene discoveries; and demonstrated ability to manage and collaborate in a multi-disciplinary team, to discover and evolve immunology-related drug discovery pipelines.

Nice To Haves

• Experience in the clinical management or medical research relating to autoimmune and immune-mediated disease is a plus.
• Individuals with proficiency in computational immunology research are particularly encouraged to apply.

Responsibilities

• Understand and leverage RGC and Regeneron datasets, external resources, and the scientific/medical literature to generate research questions and then generate relevant phenotypes from longitiudinal clinical data, design and execute genetic association studies, and perform integrative omics analyses to address these research questions
• Deploy computational methods to integrate genetic data with multiple omics data to more effectively identify/prioritize drug targets illuminated by genetic association data.
• Work closely with other members of the Immunology and other TAG teams, Analytic Genetics, Sequencing, and GIDE in cross-functional initiatives within the RGC and Regeneron.
• Collaboratively summarize insights of investigations into a variety of formats (e.g. documents, presentations, patent applications, publications, etc.) for audiences with broad bacgrounds.
• Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.

Benefits

• We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels!
• For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.
• For other countries’ specific benefits, please speak to your recruiter.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees