Associate Director, Real World Evidence Generation Ophthalmology

Dompé•San Mateo, CA

5d•$180,000 - $220,000

About The Position

The Associate Director, RWE Ophthalmology leads the design, execution, and dissemination of real-world evidence studies across Dompé’s ophthalmology portfolio, including marketed products and pipeline assets and diseases. Reporting to the Senior Director, RWE/HEOR, the role works closely with the Global Medical Indication Lead for Ophthalmology and Medical Communications to address ophthalmology-specific evidence needs with scientific rigor and strategic relevance. The evidence is intended to inform publications, HCP engagement, and, with HEOR colleagues, payor and formulary discussions. The position requires epidemiological expertise and ophthalmology therapeutic knowledge to shape study designs, data-source selection, and analytic approaches that withstand clinical, scientific, and regulatory scrutiny. The role develops an ophthalmology evidence-generation roadmap, identifies and prioritizes evidence gaps, selects appropriate real-world data sources, and designs and manages observational studies, registries, and analyses from protocol development through final reporting. It oversees interpretation, data linkage where appropriate, ethical and regulatory compliance, and study budgets, timelines, and vendor deliverables. The Associate Director also manages research partnerships, translates findings into scientific and internal communications, contributes real-world context to medical strategy and planning, and monitors developments in ophthalmology real-world evidence and registries.

Requirements

Advanced degree (MD, PhD, PharmD, or equivalent) in epidemiology, outcomes research, or a related field.
At least 5 years of experience in real-world evidence or outcomes research, including observational study design and execution.
Therapeutic experience in or strong familiarity with ophthalmology.
Experience with real-world data sources, including claims, EHR, and registries, and understanding of their methodological tradeoffs.
Strong written and verbal scientific communication skills, including experience authoring or co-authoring peer-reviewed publications.

Nice To Haves

Rare disease experience.
Existing relationships with ophthalmology KOLs or research networks.
Publication record in ophthalmology or related specialty areas.
Experience with claims-, EHR-, or registry-based ophthalmology data, including specialty registries such as the IRIS Registry.
Experience linking or integrating multiple real-world data sources, such as claims and hub or specialty pharmacy data.
Experience partnering with HEOR or Market Access functions on evidence value positioning.

Responsibilities

Build and maintain an ophthalmology real-world evidence generation roadmap across programs.
Identify and prioritize evidence gaps with the Global Medical Indication Lead for Ophthalmology, translating needs such as natural history, disease burden, treatment patterns, and comparative effectiveness into a study pipeline.
Select and evaluate suitable real-world data sources, including claims databases, EHR networks, specialty registries, and pharmaceutical hub program data.
Design and manage ophthalmology observational studies, registries, and data analyses from protocol development through statistical analysis plan and final study report.
Oversee interpretation of real-world evidence findings, appropriately accounting for data-source limitations and confounding.
Lead data linkage and integration approaches across sources where appropriate.
Ensure studies meet scientific, ethical, and regulatory standards, including appropriate IRB or ethics oversight and data privacy compliance.
Manage project budgets, timelines, and vendor deliverables for assigned studies.
Align evidence generation with medical strategy and the broader indication engagement plan in partnership with the Global Medical Indication Lead for Ophthalmology.
Manage relationships with academic investigators, data vendors, registry holders, and research partners, including scope definition, deliverable tracking, and data-use agreements.
Translate study results into publications, congress presentations, and internal insight summaries with Medical Communications.
Partner with HEOR colleagues to position real-world evidence outputs for value communication and payor-facing evidence needs where relevant.
Contribute real-world context, disease epidemiology, treatment landscape, and registry representativeness to medical strategy, publication strategy, and advisory board content development.
Monitor the ophthalmology real-world evidence and registry landscape and flag relevant new data sources, methods, and competitive activity.