Associate Director, Precision Medicine

Bristol Myers Squibb • Needham, MA

1d • $209,250 - $253,565

About The Position

Leads the development and implementation of the Model-Informed Drug Development (MIDD) strategy for drugs and other therapeutic agents in clinical development, in partnership with Clinical Pharmacology and other quantitative functions. The role places quantitative evidence at the center of development and regulatory decision-making. MIDD integrates diverse data through pharmacometric models to inform development decisions and regulatory assessments. Model-Based Meta-Analysis provides quantitative assessment of competitors and comparators to refine asset strategy. MIDD informs dose and regimen selection, clinical study hypotheses, and the clinical data package supporting regulatory assessment of clinical pharmacology and benefit-risk. Pharmacometric analyses may also influence regulatory approval decisions and, in some cases, serve as a primary basis for approval.

Requirements

• Advanced degree in a relevant scientific or quantitative field, such as an MS, PhD, or PharmD.
• At least 5 years of relevant experience, with demonstrated progression in pharmacometrics and Clinical Pharmacology knowledge and increasing scientific impact.
• Expertise in quantitative data analysis, data wrangling and transformation, visualization, population pharmacokinetic modeling, and exposure-response modeling.
• Proficiency with relevant modeling and programming tools, such as R, NONMEM, Monolix, Pumas, MATLAB, Python, and/or Julia.
• Working knowledge of the drug development process and the application of quantitative evidence to development and regulatory decision-making.
• In-depth knowledge of current practices, methodologies, and emerging issues in pharmacometrics and Clinical Pharmacology, with demonstrated interest in advancing the field.
• Strong written and verbal communication skills, including the ability to influence stakeholders and deliver compelling scientific presentations.
• Ability to translate complex modeling results into clear recommendations that influence cross-functional decisions.
• Ability to drive scientific impact in a dynamic, collaborative, and team-oriented environment.

Nice To Haves

• Experience with mechanistic modeling approaches, such as Quantitative Systems Pharmacology (QSP) and Physiologically Based Pharmacokinetic (PBPK) modeling.

Responsibilities

• Partner with the Clinical Pharmacology lead to develop the MIDD strategy and define the pharmacometric plan for assigned assets.
• Lead integration across quantitative disciplines to develop and execute a coherent modeling and data strategy.
• Lead planning, execution, interpretation, and reporting of formal pharmacometric analyses supporting clinical study reports, health authority submissions, and responses to regulatory questions.
• Translate complex modeling results into clear, actionable recommendations that inform asset strategy, development plans, and governance decisions.
• Serve as the MIDD subject matter expert, partnering with Clinical Pharmacology and other quantitative functions to influence development decisions for therapeutic agents.
• Advance pharmacometric infrastructure, tools, methodologies, and ways of working.
• Lead pharmacometric and cross-functional initiatives that strengthen quantitative decision-making across development programs.
• Provide scientific direction and oversight for pharmacometric analyses conducted by external vendors.
• Represent the MIDD strategy and provide subject matter expertise in interactions with health authorities, helping to inform regulatory strategy.
• Collaborate with internal and external subject matter experts to advance MIDD methodologies and capabilities and introduce innovative quantitative approaches into development programs.
• Provide scientific guidance and mentorship to junior scientists in pharmacometrics and MIDD.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings.
• Flexible Time Off (FTO) for eligible U.S.-based exempt employees, subject to manager approval.
• 11 paid company holidays each year.
• For eligible non-exempt employees, RayzeBio employees, and employees located in Puerto Rico: 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• Additional discretionary incentive cash and stock opportunities may be available.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior