Associate Director of Medicinal Chemistry

Integrated Biosciences, Inc.•Redwood City, CA

6d•Onsite

About The Position

Integrated Biosciences is focused on advancing small molecule therapeutics for age-related diseases. They have developed a unique discovery platform that combines phenotypic models of aging, chemistry, and AI. The company is backed by prominent VCs and has recent publications in prestigious journals like Cell, Nature, and Nature Aging. They are expanding their senior scientific team to accelerate their pipeline.

Requirements

PhD in pharmacology, physiology, cancer biology, or a related field, with 8+ years of relevant industry experience.
Deep expertise in small molecule in vivo pharmacology, including broad hands-on proficiency with rodent models of disease (oncology, metabolic, inflammation, or other therapeutic areas).
Strong understanding of PK/PD principles and experience integrating pharmacokinetic and pharmacodynamic data to guide compound optimization.
Comfort operating at both strategic and bench levels.
Demonstrated ability to lead, mentor, and build effective scientific teams.

Nice To Haves

Experience in cardiometabolic disease and/or aging biology
Experience in toxicology
Comfort with cutting-edge data analysis, large data sets, and pioneering AI approaches
Startup-ready mindset: agile, proactive, and comfortable with ambiguity in a fast-paced environment

Responsibilities

Design, execute, and interpret in vivo pharmacology studies to support lead optimization, candidate selection, and IND-enabling activities across multiple small molecule programs.
Develop, validate, and implement disease-relevant animal models (efficacy, mechanistic, and tolerability) in collaboration with internal and external teams.
Define translational pharmacology strategies, including PK/PD modeling, biomarker selection, and dose prediction frameworks to support clinical translation.
Partner with DMPK, medicinal chemistry, and biology teams to integrate in vitro and in vivo data into holistic SAR and candidate progression decisions.
Oversee vivarium staffing, scheduling, and day-to-day operations in collaboration with animal care personnel; serve as primary scientific liaison to the IACUC committee.
Communicate study results clearly to internal stakeholders through high-quality data packages, presentations, and written reports.
Contribute to IND filings, regulatory submissions, and due diligence activities as needed.
Build and mentor a growing in vivo pharmacology team; contribute to a culture of scientific excellence and collaboration.