Associate Director, Global HEOR and Evidence Generation

Encoded Therapeutics

About The Position

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for genetic disorders through genomics-driven discovery. The Associate Director, Global HEOR and Evidence Generation, is an integral member of the Medical and Patient Affairs team and reports to the Senior Director for Global HEOR and Evidence Generation. The role supports regulatory and commercial evidence-generation needs, including the HEOR and evidence-generation strategy for ETX101, a gene therapy for Dravet Syndrome, and other pipeline programs as needed. The Associate Director supports the execution of a long-term value evidence package for global stakeholders and designs and implements approaches to optimize value and patient-access discussions. The position requires understanding global evidence requirements for regulatory and health-authority submissions involving HEOR research in gene therapy. It contributes to product approval, clinical differentiation, launch readiness, commercialization, and patient access through strategic and tactical HEOR leadership. The role leads global HEOR research and evidence assessments, manages research projects and external partners, and maintains scientific rigor across proposals, protocols, and statistical analysis plans. It collaborates with Clinical, Regulatory, Commercial, Medical Affairs, and Patient Advocacy teams, supports global HTA and payer alignment, and helps build HEOR capabilities and a value-focused culture across Encoded. Domestic and international travel may be required as needed.

Requirements

Master’s degree (MS, MPH), MD, PharmD, or PhD in HEOR, Epidemiology, Biostatistics, Public Health, Psychology, or a related quantitative or scientific discipline.
At least 5 years of relevant pharmaceutical-industry or specialized-consulting experience.
Proven study-design and execution experience across observational research, Patient Experience Data, Clinical Outcome Assessments (COA/PRO) development, psychometric validation, and health economic modeling.
Demonstrated ability to lead HEOR research from conceptualization and protocol development through peer-reviewed publication and defense before global health authorities.
Direct experience preparing and delivering HEOR components for global regulatory dossiers and HTA submissions.
Excellent project-management skills, including experience managing multiple complex projects, budgets, and external vendor partnerships in rapidly changing global matrix environments.
Strong working knowledge of pharmaceutical compliance frameworks, legal and regulatory review processes, and clinical trial designs.
Exceptional interpersonal and communication skills, with the ability to use scientific expertise to influence, collaborate with, and align diverse internal and external stakeholders.
Ability to rapidly synthesize complex data to answer strategic business questions and establish cross-functional HEOR best practices.
Willingness to travel domestically and internationally as needed.

Nice To Haves

PhD in HEOR or a related scientific discipline.
Direct experience supporting programs in rare genetic disorders, neurology (including epilepsy, neurodevelopmental disorders, or pain), or advanced therapeutics such as gene and cell therapies.
Hands-on experience supporting assets through late-stage development, pre-launch commercialization, and global launch execution.

Responsibilities

Shape, align, and support execution of global HEOR strategies for product approval, clinical differentiation, and optimal patient access.
Maintain understanding of global HTA requirements, major ex-US HTA bodies, and the evolving US payer and value-assessment landscape to inform evidence generation.
Execute HEOR-related commercial strategies supporting successful asset launches.
Serve as an HEOR subject-matter expert and collaborate with Clinical, Regulatory, Commercial, Medical Affairs, and Patient Advocacy teams on global evidence-generation strategy.
Maintain working knowledge of global regulatory guidelines, internal compliance policies, and Medical-Legal-Regulatory review processes to ensure ethical and compliant activities.
Lead global HEOR research initiatives, potentially including literature reviews, natural history, disease burden, observational research, COA/PRO research, and health economic and epidemiological modeling.
Lead systematic landscape assessments and data-gap analyses to inform asset strategy, contextualize disease burden, and identify data sources.
Oversee research planning, budgeting, execution, and timely dissemination of findings, including management of external vendors and scientific partnerships.
Maintain scientific rigor and quality across research proposals, protocols, and statistical analysis plans, and support defense of research in internal and external forums.
Develop and implement HEOR best practices, governance frameworks, and educational resources as needed to scale organizational capabilities.
Champion the HEOR and payer perspective and contribute to initiatives that embed a value-driven mindset across the organization.
Support research initiatives and global business priorities through domestic and international travel as needed.

Benefits

Comprehensive benefits package, including competitive employer premium contributions.
Meaningful stock option grants.
PTO, sick time, and holiday pay.
Generous parental leave program.
Pre-tax medical and dependent care programs.
Short-term disability, long-term disability, life, and AD&D coverage.
Professional development opportunities.
Team-building events.
Fully stocked micro-kitchen.
Fitness center at the South San Francisco location.