Scientist I

KBI Biopharma•Louisville, KY

2d•Onsite

About The Position

KBI Biopharma is seeking a highly skilled and motivated Analytical Scientist to join our Analytical and Formulation Sciences (AFS) team in Louisville, CO. This role is ideal for a scientist with deep expertise in protein analytics, ideally with a background in mass spectrometry and protein structural characterization. You will serve as a subject matter expert (SME), driving innovation and excellence in analytical testing to support client programs from early development through late-phase and commercialization for biotherapeutics.

Requirements

Ph.D. in Biochemistry, Analytical Chemistry, or a related field with 0-3 years experience; M.S. with 3-7 years experience; B.S. degree with >7 years experience.
Adaptability to changing priorities and business needs.
Adherence to statutory and company safety requirements.
Strong understanding of protein structure and stability and degradation pathways leading to PTMs.
Excellent communication skills and ability to present complex data to diverse audiences.
Proficiency in scientific software and data analysis tools (e.g. Excel, Prism).
Ability to work independently and collaboratively in a fast-paced environment.

Nice To Haves

Deep expertise in protein analytics
Background in mass spectrometry and protein structural characterization

Responsibilities

Demonstrates expertise in the execution and interpretation of experiments that contribute to project goals.
Expertise in mass spectrometry techniques including intact mass and subunit analysis, reduced and non-reduced peptide mapping, and PTM and sequence variant analysis.
Significant experience is desired in optimizing multiple chromatographic modalities relevant to mass spectrometry, including SEC, RP, HILIC, and CEX.
Familiarity with Agilent, Waters, and Thermo LC-MS systems.
Occasional recourse to non LC-MS methods including capillary electrophoresis (SDS-CGE and icIEF), UV/Fluorescence, compendial methods, and biophysical characterization techniques on proteins (CD, FTIR, DLS, SEC-MALS, calorimetry).
Design and strategically execute analytical experiments in support of biotherapeutics development, particularly qualification/validation and stability studies.
Generate high-quality documentation suitable for publication and regulatory review, including technical documents and analytical test methods.
Act as SME on client programs, providing technical guidance and representing KBI in client interactions.
Collaborate cross-functionally with rapid analytics, process development, bioassay, and program management teams.
Mentor and train junior scientists and associates.
Perform peer review of data and reports related to method development, qualification, and validation, as well as characterization and stability study reports.
Manage timelines and resources to meet project milestones and proactively advise leadership on program status and technical challenges.