Analytical Scientist I

Prolific Machines•Emeryville, CA

2d•$120,000 - $140,000•Onsite

About The Position

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments. This role will be based on-site in Emeryville, CA.

Requirements

Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
Have hands-on experience operating LC-MS.
Are highly motivated to deliver successful outcomes for internal and external clients.
Are excited to work with internal and external clients to deliver project excellence.
Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.

Nice To Haves

Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.

Responsibilities

Develop, optimize, and validate assays for protein quality and purity for broad classes of recombinant therapeutic proteins.
Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
Execute, summarize, and interpret routine and complex therapeutic protein characterizations.
Qualify and validate assays upholding highly rigorous standards for execution and documentation.
Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
Author, review, and implement methods, protocols, validations, and standard operating procedures.
Ensure processes are followed in accordance with these standards.