VP, Medicine Development Leader, Oncology - GI

GSK • Waltham, PA

3d • Hybrid

About The Position

The VP, Medicine Development Leader (MDL) strategically leads the global development of an oncology medicine at the asset level and serves as the single point of accountability from clinical Proof of Concept (PoC) through approval in the first major market or markets. The MDL works across GSK’s Medicine Development matrix—including R&D, Manufacturing, and Commercial—to define the medicine’s strategic vision and operational plan in alignment with organizational strategy. The MDL creates and leads a multidisciplinary, matrixed Medicine Development Team (MDT), bringing together the functions needed to deliver the medicine.

The role partners with the Early Development Lead to transition lead indications after clinical PoC and with the Medicine Commercial Lead through approval. After approval in the first major markets, the MDL supports the Medicine Commercial Team with registration, post-marketing requirements, and lifecycle management. The MDL also partners with R&D Business Development on development planning for prospective in-licensed assets, including medicine profiles and plans addressing clinical feasibility, regulatory planning, and CMC risks.

The MDL establishes the asset vision and development strategy, prioritizes development options and indications, and makes evidence-based go/no-go and acceleration decisions. The role oversees governance and execution across clinical studies, patient safety and pharmacovigilance, scientific engagement, and promotional practices; incorporates patient input into development plans; and engages external communities including physicians, regulators, patients, and payers. The MDL represents the asset to senior management, governance bodies, and external advisory committees, and is accountable for the asset’s people and financial resourcing plan and budget.

This is a hybrid position requiring on-site presence at least two days per week at one of GSK’s listed US, Switzerland, or UK sites. For candidates based at the Stevenage site, the role will temporarily be based there before a planned office relocation to Cambridge, UK, currently proposed by early 2029.

Requirements

• Advanced degree, including MD, PhD, PharmD, MBA, or MS.
• Oncology drug-development experience in the global pharmaceutical and/or biotechnology industry.
• Filing experience with BLA, NDA, or MAA submissions as a core responsibility.
• Experience across the oncology drug-development lifecycle, including Discovery, late-stage Development, Regulatory, Manufacturing, Medical, and Commercial.
• Experience in oncology product development and/or commercialization, late-phase development from clinical PoC onward, clinical trial management, post-approval studies, and regulatory and manufacturing compliance.
• Experience leading teams in a complex, matrixed, global, multidisciplinary organization with high accountability, minimal authority, and multiple reporting lines.
• Experience working with regulators and regulatory requirements, including legal and government frameworks across global geographies.
• Experience creating strategies for pre- and post-marketing studies and driving lifecycle processes.
• Experience building budgets and leading strategic and budget planning.
• Experience in the healthcare environment and access in all major markets.

Nice To Haves

• Experience leading oncology drug-development programs in gastrointestinal (GI) or pancreatic cancers.
• Highly developed ethics and integrity, with demonstrated ethical medical decision-making skills.
• Strong matrix leadership and motivational skills.
• Ability to collaborate successfully across Research, Commercial, Regulatory, Global Medicine Supply, Legal, and regional functions.
• Skills listed: Business Strategies, Collaborative Partnerships, Commercial Acumen, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Innovative Leadership, Matrix Leadership, Prioritization, Scientific Data Analysis, Scientific Presentations, and Team Development.

Responsibilities

• Act as GSK’s single point of accountability for all aspects of the medicine’s global development from clinical PoC through approval in the first major market or markets.
• Partner with the Early Development Lead and Medicine Commercial Lead to ensure smooth transitions of lead indications after PoC and upon approval.
• After approval, support the Medicine Commercial Team in the first major markets, including registration, post-marketing requirements, and lifecycle management.
• Select MDT members with functional line Heads, lead the multidisciplinary matrix team, support team-member development, own MDT performance, and partner with Line Managers to drive performance.
• Partner with the Pipeline Project Manager to motivate and lead the MDT, set objectives, and drive operational delivery, including consideration of acceleration, parallel indication development, and informed risk-taking.
• Partner with R&D Business Development to develop plans for prospective in-licensed assets, including a Medicine Profile and plans for clinical feasibility, regulatory planning, and CMC risk mitigation.
• Establish the medicine’s vision and profile, align asset strategy with R&D strategy and the competitive landscape, and translate strategy into actionable plans.
• Deliver differentiated medicines through evidence packages supporting regulatory approval, market access, and product lifecycle needs.
• Prioritize and maximize development options, including development across multiple indications.
• Partner with the Global Medical Lead and Medicine Commercial Lead on indication expansion and lifecycle-management plans.
• Make evidence-based go/no-go and acceleration decisions and identify inflection points based on whether results meet the medicine’s strategy.
• Ensure effective governance and execution, including oversight of clinical studies, patient safety and pharmacovigilance, scientific engagement, and promotional practices with relevant matrix leads.
• Incorporate the patient voice into development plans.
• Increase visibility and engagement with physicians, regulators, patients, and payers to address unmet medical needs and support GSK’s reputation.
• Serve as the asset’s point of contact and spokesperson to senior management, governance committees, and external advisory committees as needed.
• Deliver and manage the asset resourcing plan, including people and finances, and manage the asset budget to the agreed variance with the Pipeline Project Manager and Finance Partner.

Benefits

• Annual bonus.
• Eligibility to participate in a share-based long-term incentive program, dependent on role level.
• Health care and other insurance benefits for employees and family.
• Retirement benefits.
• Paid holidays and vacation.
• Paid caregiver/parental and medical leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive